Dual roles of FAK in tumor angiogenesis: A review focused on pericyte FAK

Focal adhesion kinase (FAK), also known as protein tyrosine kinase 2 (PTK2), is a ubiquitously expressed non-receptor tyrosine kinase, that plays a pivotal role in integrin-mediated signal transduction. Endothelial FAK is upregulated in many types of cancer and promotes tumorigenesis and tumor progr...

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Bibliographic Details
Published in:European journal of pharmacology 2023-05, Vol.947, p.175694-175694, Article 175694
Main Authors: Zhang, Jingyu, Li, Wei, Wang, Wenxin, Chen, Qingqing, Xu, Zishan, Deng, Meijing, Zhou, Lin, He, Guoyang
Format: Article
Language:English
Subjects:
Carcinogenesis - metabolism
Endothelial Cells - metabolism
FAK
FAK inhibitors
Focal Adhesion Kinase 1 - metabolism
Focal Adhesion Protein-Tyrosine Kinases - metabolism
Humans
Neoplasms - pathology
Neovascularization, Pathologic - metabolism
Pericyte
Pericytes - metabolism
Pericytes - pathology
Tumor angiogenesis
Vasculogenic mimicry
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Summary:Focal adhesion kinase (FAK), also known as protein tyrosine kinase 2 (PTK2), is a ubiquitously expressed non-receptor tyrosine kinase, that plays a pivotal role in integrin-mediated signal transduction. Endothelial FAK is upregulated in many types of cancer and promotes tumorigenesis and tumor progression. However, recent studies have shown that pericyte FAK has the opposite effect. This review article dissects the mechanisms, by which endothelial cells (ECs) and pericyte FAK regulate angiogenesis, with an emphasis on the Gas6/Axl pathway. In particular, this article discusses the role of pericyte FAK loss on angiogenesis during tumorigenesis and metastasis. In addition, the existing challenges and future application of drug-based anti-FAK targeted therapies will be discussed to provide a theoretical basis for further development and use of FAK inhibitors.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2023.175694