Plasma insulin is required for the increase in plasma angiopoietin‐like protein 8 in response to nutrient ingestion

Background Plasma levels of angiopoietin‐like protein 8 (ANGPTL8) are regulated by feeding and they increase following glucose ingestion. Because both plasma glucose and insulin increase following food ingestion, we aimed to determine whether the increase in plasma insulin and glucose or both are re...

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Published in:Diabetes/metabolism research and reviews 2023-09, Vol.39 (6), p.e3643-n/a
Main Authors: Abu‐Farha, Mohamed, Alatrach, Mariam, Abubaker, Jehad, Al‐Khairi, Irina, Cherian, Preethi, Agyin, Krisitn, Abdelgani, Siham, Norton, Luke, Adams, John, Al‐Saeed, Dalal, Al‐Ozairi, Ebaa, DeFronzo, Ralph A., Al‐Mulla, Fahd, Abdul‐Ghani, Muhammad
Format: Article
Language:English
Subjects:
Angiopoietin
ANGPTL8
Fasting
Glucose
Glucose tolerance
Insulin
Plasma
Plasma levels
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Summary:Background Plasma levels of angiopoietin‐like protein 8 (ANGPTL8) are regulated by feeding and they increase following glucose ingestion. Because both plasma glucose and insulin increase following food ingestion, we aimed to determine whether the increase in plasma insulin and glucose or both are responsible for the increase in ANGPTL8 levels. Methods ANGPTL8 levels were measured in 30 subjects, 14 with impaired fasting glucose (IFG), and 16 with normal fasting glucose (NFG); the subjects received 75g glucose oral Glucose tolerance test (OGTT), multistep euglycaemic hyperinsulinemic clamp and hyperglycaemic clamp with pancreatic clamp. Results Subjects with IFG had significantly higher ANGPTL8 than NGT subjects during the fasting state (p 
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.3643