Association of blood pressure and hyperuricemia with proteinuria and reduced renal function in the general population

This study aimed to investigate the effect of hyperuricemia (HU) on the association of systolic blood pressure (SBP) with the prevalence of proteinuria and low estimated glomerular filtration rate (eGFR) in the general population. This cross-sectional study enrolled 24,728 Japanese individuals (11,1...

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Bibliographic Details
Published in:Hypertension research 2023-07, Vol.46 (7), p.1662-1672
Main Authors: Kochi, Masako, Kohagura, Kentaro, Oshiro, Nanako, Zamami, Ryo, Nagahama, Kazufumi, Nakamura, Koshi, Ohya, Yusuke
Format: Article
Language:English
Subjects:
Blood pressure
Blood Pressure - physiology
Cross-Sectional Studies
Female
Glomerular Filtration Rate - physiology
Humans
Hypertension
Hyperuricemia - complications
Hyperuricemia - epidemiology
Kidney - physiology
Kidney diseases
Male
Proteinuria - epidemiology
Public health
Renal Insufficiency, Chronic
Risk Factors
Uric Acid
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Summary:This study aimed to investigate the effect of hyperuricemia (HU) on the association of systolic blood pressure (SBP) with the prevalence of proteinuria and low estimated glomerular filtration rate (eGFR) in the general population. This cross-sectional study enrolled 24,728 Japanese individuals (11,137 men and 13,591 women) who underwent health checkups in 2010. The prevalence of proteinuria and low eGFR ( 7.2 and > 5.4 mg/dL, respectively). The odds ratio (OR) for proteinuria increased with elevated SBP. This trend was significantly evident in participants with HU. Moreover, there was an interactive effect of SBP and HU on the prevalence of proteinuria in the male (P  = 0.04) and female (P  = 0.04) participants. Next, we evaluated the OR for low eGFR (
ISSN:0916-9636
1348-4214
DOI:10.1038/s41440-023-01250-w