Stratifin promotes the growth and proliferation of hepatocellular carcinoma

• Published in: Tissue & cell 2023-06, Vol.82, p.102080-102080, Article 102080
• Main Authors: Zhao, Xinyu, Wang, Enqin, Xu, Hongkun, Zhang, Lihong
• Format: Article
• Language: English
• Subjects: Apoptosis; Apoptosis - genetics; Carcinoma, Hepatocellular - pathology; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Gene Expression Regulation, Neoplastic; Hepatocellular carcinoma; Humans; Liver Neoplasms - pathology; Malignant Progression; Proliferation; Protein Interaction Maps; Signal Transduction; Stratifin
• ISSN: 0040-8166; 1532-3072
• DOI: 10.1016/j.tice.2023.102080

Hepatocellular carcinoma (HCC) is the second leading cancer cause of death worldwide. SFN plays a vital role in some malignancies. The purpose of this study was to investigate the role of SFN in the development of HCC. The bioinformatics database was used to detect the expression of SFN and its prognosis in HCC patients. And the protein-protein interaction network was established. IHC and Elisa were used to analyze the expression level and clinical characteristics of SFN in HCC patients. Subsequently, siRNA knockdown of SFN expression in HCC cell lines was used to explore whether SFN could promote the development of HCC. SFN was highly expressed in the tissues and serum of hepatocellular carcinoma, and its expression level was correlated with the tumor which was single or not in patients. Bioanalysis and histochemistry results showed that CDC25B was co-expressed with SFN in HCC, which may be the upstream and downstream signaling molecule of SFN. Knockdown of SFN can inhibit cell proliferation, migration, invasion and promote apoptosis. Our results suggest that SFN may play an important role in HCC progression and may interact with CDC25B to promote malignant progression of HCC, providing a molecular target for future HCC therapy. •Stratifin is highly expressed in liver cancer tissues and serum.•Stratifin may be a marker for treatment and prognosis of liver cancer.•Stratifin can promote hepatocellular carcinoma proliferation, invasion and migration, and inhibit apoptosis.•Stratifin may modulate HCC malignant progression through CDC25B.