Untargeted metabolomics reveals the preventive effect of quercetin on nephrotoxicity induced by four organophosphorus pesticide mixtures

This research aimed to explore the protective effect of quercetin against nephrotoxicity induced by four organophosphate pesticide mixtures (PM) using untargeted metabolomics technology in rat kidneys. Sixty male Wistar rats were randomly divided into six groups: control, low-dose quercetin treated...

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Bibliographic Details
Published in:Food and chemical toxicology 2023-05, Vol.175, p.113747-113747, Article 113747
Main Authors: Hou, Yali, Ding, Tingting, Guan, Zhiyu, Wang, Jing, Yao, Ranqi, Yu, Ziran, Zhao, Xiujuan
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Glycerophospholipids - pharmacology
Glycerophospholipids - therapeutic use
Insecticides - pharmacology
Kidney Diseases - chemically induced
Kidney Diseases - drug therapy
Kidney Diseases - prevention & control
Male
Metabolomics
Nephrotoxicity
Organophosphates - adverse effects
Organophosphorus Compounds
Organophosphorus pesticide mixtures
Oxidative Stress
Pesticides - adverse effects
Purines
Quercetin
Quercetin - pharmacology
Quercetin - therapeutic use
Rats
Rats, Wistar
Untargeted metabolomics
Vitamin B 6 - pharmacology
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Summary:This research aimed to explore the protective effect of quercetin against nephrotoxicity induced by four organophosphate pesticide mixtures (PM) using untargeted metabolomics technology in rat kidneys. Sixty male Wistar rats were randomly divided into six groups: control, low-dose quercetin treated (10 mg/kg bw), high-dose quercetin treated (50 mg/kg bw), PM-treated, and two dosages of quercetin + PM-treated. Metabolomics results showed that 17 differential metabolites were identified in the PM-treated group, and pathway analysis revealed that renal metabolic disorders include purine metabolism, glycerophospholipid metabolism, and vitamin B6 metabolism. When high-dose quercetin and PM-treated were administered to rats concurrently, the intensities of differential metabolites were substantially restored (p 
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2023.113747