A progressive T cell exhaustion program mapped across tissues in patients with lung cancer on immune checkpoint blockade

Immune checkpoint blockade has reached the standard of care for patients with lung cancer. However, its mode of action in patients is still incompletely understood. In this issue, Pai et al. present a temporally and spatially resolved differentiation map of tumor-directed T cells in patients with lu...

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Bibliographic Details
Published in:Cancer cell 2023-04, Vol.41 (4), p.653-655
Main Authors: Mangana, Carolina, Maier, Barbara B.
Format: Article
Language:English
Subjects:
B7-H1 Antigen
CD8-Positive T-Lymphocytes
Humans
Immune Checkpoint Inhibitors - therapeutic use
Lung Neoplasms - drug therapy
T-Cell Exhaustion
T-Lymphocytes
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Summary:Immune checkpoint blockade has reached the standard of care for patients with lung cancer. However, its mode of action in patients is still incompletely understood. In this issue, Pai et al. present a temporally and spatially resolved differentiation map of tumor-directed T cells in patients with lung cancer on PD-1 blockade. Immune checkpoint blockade has reached the standard of care for patients with lung cancer. However, its mode of action in patients is still incompletely understood. In this issue, Pai et al. present a temporally and spatially resolved differentiation map of tumor-directed T cells in patients with lung cancer on PD-1 blockade.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2023.02.020