Gold self-relay catalysis enabling annulative oxygenation of propargylic alcohols with O-nucleophiles

A new gold( i ) self-relay catalysis reaction enabling the annulative oxygenation of propargylic alcohols with various O-nucleophiles, such as carboxylic acids, alcohols and TBHP, is reported, producing a series of functionalized benzofurans in moderate to good yields under mild conditions. This pro...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2023-03, Vol.59 (27), p.432-435
Main Authors: Hao, Meng-Ying, Zhang, Yin, Lin, Na, Fu, Rong, Ji, Xiao-Shuang, Jiang, Bo, Tu, Shu-Jiang, Hao, Wen-Juan
Format: Article
Language:English
Subjects:
Alcohols
Carboxylic acids
Catalysis
Functional groups
Gold
Lewis acid
Nucleophiles
Oxygenation
Relay
Substrates
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Summary:A new gold( i ) self-relay catalysis reaction enabling the annulative oxygenation of propargylic alcohols with various O-nucleophiles, such as carboxylic acids, alcohols and TBHP, is reported, producing a series of functionalized benzofurans in moderate to good yields under mild conditions. This protocol benefits from the π- and σ-Lewis acid capability of gold complexes, demonstrating high molecular convergence, broad substrate flexibility, high functional group compatibility and mild conditions. A new gold( i ) self-relay catalysis reaction enabling the annulative oxygenation of propargylic alcohols with various O-nucleophiles, such as carboxylic acids, alcohols and TBHP, is reported, producing a series of functionalized benzofurans.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc00089c