Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial

Background Inflammatory and non‐inflammatory acne lesions constitute a significant clinical challenge in acne subjects. Aim To evaluate the efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid for improving skin conditions. Methods This randomized controlle...

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Bibliographic Details
Published in:Journal of cosmetic dermatology 2023-09, Vol.22 (9), p.2502-2511
Main Authors: Li, Shuting, He, Xiaofeng, Zhang, Zhongxing, Zhang, Xianghua (Succi), Niu, Yueqing (Gloria), Steel, Andrew, Wang, Hequn (Tracy)
Format: Article
Language:English
Subjects:
Acids
Acne
acne vulgaris
comedones
Hydration
lipohydroxy acid
Normal distribution
salicylic acid
skin barrier
Skin cancer
Statistical analysis
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Summary:Background Inflammatory and non‐inflammatory acne lesions constitute a significant clinical challenge in acne subjects. Aim To evaluate the efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid for improving skin conditions. Methods This randomized controlled trial included adults with comedones, post‐inflammatory erythema (PIE) and/or hyperpigmentation (PIH) in Shanghai, China in July 2021. Participants were randomly assigned 1:1 to receive the study Serum + Mask or serum alone for 8 weeks. Acne severity, comedones, papules, pustules, PIE, PIH, skin pores, skin tone evenness, sebum secretion, skin hydration, and trans‐epidermal water loss were evaluated at T0d, T1d, T7d, T14d, T28d, and T56d. Results Eighty‐three participants were included, including 41 and 42 in the Serum + Mask and Serum groups, respectively. Acne severity, density of skin pores, skin tone evenness, PIH foci on face, PIE foci on nose, intensity of PIE and PIH, closed comedones on face, open comedones on nose, sebum secretion, and skin hydration were significantly improved from baseline after 8 weeks of treatment in both groups (all p 
ISSN:1473-2130
1473-2165
DOI:10.1111/jocd.15746