Spatial epigenome–transcriptome comapping technology

Spatial omics facilitate an in-depth understanding of cell states and cell interactions. Recent work by Zhang et al. simultaneously seizes spatial epigenetic priming, differentiation, and gene regulation at nearly single-cell resolution by developing an epigenome–transcriptome comapping technology....

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Bibliographic Details
Published in:Trends in cell biology 2023-06, Vol.33 (6), p.449-450
Main Authors: Jin, Ming-Zhu, Jin, Wei-Lin
Format: Article
Language:English
Subjects:
epigenome
Epigenome - genetics
gene expression
Gene Expression Regulation
Genome
single-cell resolution
spatial omics
Technology
transcriptome
Transcriptome - genetics
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Summary:Spatial omics facilitate an in-depth understanding of cell states and cell interactions. Recent work by Zhang et al. simultaneously seizes spatial epigenetic priming, differentiation, and gene regulation at nearly single-cell resolution by developing an epigenome–transcriptome comapping technology. This work displays how epigenetic features influence cell dynamics and transcriptional phenotypes at spatial and genome-wide levels.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2023.03.011