Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation

There is a pandemic of physical inactivity that appears to parallel the widespread prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise can play an important role not only in primary cardiovascular prevention but also in secondary prevention. This review discu...

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Bibliographic Details
Published in:European heart journal 2023-06, Vol.44 (21), p.1874-1889
Main Authors: Valenzuela, Pedro L, Ruilope, Luis M, Santos-Lozano, Alejandro, Wilhelm, Matthias, Kränkel, Nicolle, Fiuza-Luces, Carmen, Lucia, Alejandro
Format: Article
Language:English
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Summary:There is a pandemic of physical inactivity that appears to parallel the widespread prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise can play an important role not only in primary cardiovascular prevention but also in secondary prevention. This review discusses some of the main cardiovascular effects of PA/exercise and the mechanisms involved, including a healthier metabolic milieu with attenuation of systemic chronic inflammation, as well as adaptations at the vascular (antiatherogenic effects) and heart tissue (myocardial regeneration and cardioprotection) levels. The current evidence for safe implementation of PA and exercise in patients with CVD is also summarized.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehad170