Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement

The Cucurbitaceae family produces a class of secondary metabolites known as cucurbitacins. The eight cucurbitacin subunits are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R with the most significant anticancer activity. They are reported to inhibit cell proliferation, invasion, and migration;...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2023-09, Vol.396 (9), p.1867-1878
Main Authors: Kumar, Ajay, Sharma, Bunty, Sharma, Ujjawal, Parashar, Gaurav, Parashar, Nidarshana Chaturvedi, Rani, Isha, Ramniwas, Seema, Kaur, Satwinderjeet, Haque, Shafiul, Tuli, Hardeep Singh
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Antioxidants
Antitumor activity
Apoptosis
Archives & records
Biomedical and Life Sciences
Biomedicine
Cancer
Cell cycle
Cell migration
Cell proliferation
Colorectal cancer
Free radicals
Health sciences
Herbal medicine
Lung cancer
MAP kinase
Metabolites
Neurosciences
Pharmacology/Toxicology
R&D
Research & development
Review
Secondary metabolites
Stat3 protein
Trends
Wnt protein
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Summary:The Cucurbitaceae family produces a class of secondary metabolites known as cucurbitacins. The eight cucurbitacin subunits are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R with the most significant anticancer activity. They are reported to inhibit cell proliferation, invasion, and migration; induce apoptosis; and encourage cell cycle arrest, as some of their modes of action. The JAK-STAT3, Wnt, PI3K/Akt, and MAPK signaling pathways, which are essential for the survival and apoptosis of cancer cells, have also been shown to be suppressed by cucurbitacins. The goal of the current study is to summarize potential molecular targets that cucurbitacins could inhibit in order to suppress various malignant processes. The review is noteworthy since it presents all putative molecular targets for cucurbitacins in cancer on a single podium.
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-023-02471-z