Ameliorative effect of resveratrol against cymoxanil‐mancozeb induced toxicity in rats

This study was conducted to evaluate the cymoxanil‐mancozeb (CM) toxicity and investigate the ameliorative effect of resveratrol (Res) against cymoxanil‐mancozeb toxicity. Forty rats were divided into four groups; the first group was used as a control group, the second group was exposed to Res only...

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Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2023-06, Vol.37 (6), p.e23347-n/a
Main Authors: Mohamed, Wafaa H., El‐Amir, Yasmin O., Yahia, Doha
Format: Article
Language:English
Subjects:
Animals
Bioassays
Blood
Body Weight
Cholesterol
Comet assay
cymoxanil
DNA damage
Fungicides
Glucose
Glucose - pharmacology
Hematology
High density lipoprotein
Intestine
Leukocytes (granulocytic)
Lipids
Liver
Liver - pathology
Lymphocytes
Mancozeb
Monocytes
Rats
Resveratrol
Resveratrol - pharmacology
Small intestine
Toxicity
Triglycerides
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Summary:This study was conducted to evaluate the cymoxanil‐mancozeb (CM) toxicity and investigate the ameliorative effect of resveratrol (Res) against cymoxanil‐mancozeb toxicity. Forty rats were divided into four groups; the first group was used as a control group, the second group was exposed to Res only at a dose of 20 mg/kg body weight for 4 weeks, and the third group was administered CM only at a dose of 799 mg/kg body weight for 4 weeks, The fourth group was co‐treated with Res+CM for 4 weeks. Blood samples were analyzed for hematological and biochemical parameters. The comet assay was done on liver and blood specimens and histopathological examinations of the liver and intestine. The results demonstrated that CM exposure caused a significant increase in WBCs, lymphocytes, granulocytes, monocytes ALT, AST, ALP, and GGT, and total cholesterol and triglycerides levels accompanied by a decrease in HGB, HCT, RBCs and MCV, MCH, MCHC, HDL and glucose levels with no significant DNA damage in liver and blood. CM mixture induced severe pathological changes in small intestine and liver. Co‐treatment of Res with CM improved hematological picture, lipid and glucose profiles also liver enzymes and decreased changes in the architecture of the liver and intestine.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.23347