Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model

Objectives This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM). Materials and methods Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30,...

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Published in:Clinical oral investigations 2023-07, Vol.27 (7), p.3839-3853
Main Authors: Inada, Rafaela Nanami Handa, Queiroz, Marcela Borsatto, Lopes, Camila Soares, Silva, Evelin Carine Alves, Torres, Fernanda Ferrari Esteves, da Silva, Guilherme Ferreira, Guerreiro-Tanomaru, Juliane Maria, Cerri, Paulo Sérgio, Tanomaru-Filho, Mário
Format: Article
Language:English
Subjects:
Aluminum Compounds - chemistry
Aluminum Compounds - pharmacology
Animals
Biocompatibility
Biological activity
Calcium Compounds - chemistry
Calcium Compounds - pharmacology
Capsules
Dental restorative materials
Dental sealants
Dentin
Dentistry
Drug Combinations
Inflammation
Interleukin 6
Materials Testing
Medicine
Mineralization
Osteocalcin
Oxides - chemistry
Porosity
Rats
Root Canal Filling Materials - chemistry
Silicates - chemistry
Silicates - pharmacology
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Summary:Objectives This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM). Materials and methods Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey’s tests ( p  
ISSN:1436-3771
1432-6981
1436-3771
DOI:10.1007/s00784-023-05002-5