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Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model
Objectives This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM). Materials and methods Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30,...
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| Published in: | Clinical oral investigations 2023-07, Vol.27 (7), p.3839-3853 |
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| creator | Inada, Rafaela Nanami Handa Queiroz, Marcela Borsatto Lopes, Camila Soares Silva, Evelin Carine Alves Torres, Fernanda Ferrari Esteves da Silva, Guilherme Ferreira Guerreiro-Tanomaru, Juliane Maria Cerri, Paulo Sérgio Tanomaru-Filho, Mário |
| description | Objectives
This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM).
Materials and methods
Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey’s tests (
p
|
| doi_str_mv | 10.1007/s00784-023-05002-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2795357077</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2834539267</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-ba80021735594c7ff8abcbba37d8a98e10b23aeb2bc6aa62a4e5706756b183033</originalsourceid><addsrcrecordid>eNp9kc1O3TAQhS1UBJT2BbqoLHXDglA7juPcZYtoQUJiQ9fW2JlURkmc2k6lu-HZO5dLf9QFG3us-c4ZjQ9j76S4kEKYj5mOrqlErSqhhagrfcBOZKPaShkjX_1TH7PXOT8IIZvWqCN2rAyVWrQn7PFziD5OC5TgwhjK9py7EMGX8BP5EgvOJcB4TmWK-akNc8_DXDAN4JFeMG5zyNzD6MM68UwuHgryhAuExD1O5JFJwoH3O7uZl9Uhn2KP4xt2OMCY8e3zfcq-fbm6v7yubu--3lx-uq28MrpUDjraTxql9abxZhg6cN45UKbvYNOhFK5WgK52vgVoa2hQG9Ea3TrZKaHUKTvb-y4p_lgxFzuF7HEcYca4ZlubjVYkMYbQD_-hD3FNtCZRnWq02tTtjqr3lKd_yQkHu6QwQdpaKewuHbtPx1I69ikdq0n0_tl6dRP2fyS_4yBA7YFMrfk7pr-zX7D9BShjm8c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2834539267</pqid></control><display><type>article</type><title>Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model</title><source>Springer Nature</source><creator>Inada, Rafaela Nanami Handa ; Queiroz, Marcela Borsatto ; Lopes, Camila Soares ; Silva, Evelin Carine Alves ; Torres, Fernanda Ferrari Esteves ; da Silva, Guilherme Ferreira ; Guerreiro-Tanomaru, Juliane Maria ; Cerri, Paulo Sérgio ; Tanomaru-Filho, Mário</creator><creatorcontrib>Inada, Rafaela Nanami Handa ; Queiroz, Marcela Borsatto ; Lopes, Camila Soares ; Silva, Evelin Carine Alves ; Torres, Fernanda Ferrari Esteves ; da Silva, Guilherme Ferreira ; Guerreiro-Tanomaru, Juliane Maria ; Cerri, Paulo Sérgio ; Tanomaru-Filho, Mário</creatorcontrib><description>Objectives
This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM).
Materials and methods
Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey’s tests (
p
< 0.05).
Results
IRM capsules were thicker and contained greater ICs and IL-6-immunopositive cells at 7 and 15 days. BIOC-R capsules exhibited higher thickness and ICs at 7 days and greater IL-6 at 7 and 15 days than MTAHP (
p
< 0.05). At 30 and 60 days, no significant difference was observed among the groups. OCN-immunopositive cells, von Kossa-positive, and birefringent structures were observed in BIOC-R and MTAHP. MTAHP exhibited higher porosity and interface voids (
p
< 0.05).
Conclusions
BIOC-R, MTAHP, and IRM are biocompatible. Bioceramics materials demonstrate bioactive potential. MTAHP presented the highest porosity and presence of voids.
Clinical relevance
BIOC-R and MTAHP have adequate biological properties. BIOC-R demonstrated lower porosity and presence of voids, which may represent better sealing for its clinical applications.</description><identifier>ISSN: 1436-3771</identifier><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-023-05002-5</identifier><identifier>PMID: 37014506</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biocompatibility ; Biological activity ; Dental restorative materials ; Dental sealants ; Dentin ; Dentistry ; Inflammation ; Interleukin 6 ; Medicine ; Mineralization ; Osteocalcin ; Porosity</subject><ispartof>Clinical oral investigations, 2023-07, Vol.27 (7), p.3839-3853</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-ba80021735594c7ff8abcbba37d8a98e10b23aeb2bc6aa62a4e5706756b183033</citedby><cites>FETCH-LOGICAL-c375t-ba80021735594c7ff8abcbba37d8a98e10b23aeb2bc6aa62a4e5706756b183033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37014506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inada, Rafaela Nanami Handa</creatorcontrib><creatorcontrib>Queiroz, Marcela Borsatto</creatorcontrib><creatorcontrib>Lopes, Camila Soares</creatorcontrib><creatorcontrib>Silva, Evelin Carine Alves</creatorcontrib><creatorcontrib>Torres, Fernanda Ferrari Esteves</creatorcontrib><creatorcontrib>da Silva, Guilherme Ferreira</creatorcontrib><creatorcontrib>Guerreiro-Tanomaru, Juliane Maria</creatorcontrib><creatorcontrib>Cerri, Paulo Sérgio</creatorcontrib><creatorcontrib>Tanomaru-Filho, Mário</creatorcontrib><title>Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM).
Materials and methods
Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey’s tests (
p
< 0.05).
Results
IRM capsules were thicker and contained greater ICs and IL-6-immunopositive cells at 7 and 15 days. BIOC-R capsules exhibited higher thickness and ICs at 7 days and greater IL-6 at 7 and 15 days than MTAHP (
p
< 0.05). At 30 and 60 days, no significant difference was observed among the groups. OCN-immunopositive cells, von Kossa-positive, and birefringent structures were observed in BIOC-R and MTAHP. MTAHP exhibited higher porosity and interface voids (
p
< 0.05).
Conclusions
BIOC-R, MTAHP, and IRM are biocompatible. Bioceramics materials demonstrate bioactive potential. MTAHP presented the highest porosity and presence of voids.
Clinical relevance
BIOC-R and MTAHP have adequate biological properties. BIOC-R demonstrated lower porosity and presence of voids, which may represent better sealing for its clinical applications.</description><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Dental restorative materials</subject><subject>Dental sealants</subject><subject>Dentin</subject><subject>Dentistry</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Medicine</subject><subject>Mineralization</subject><subject>Osteocalcin</subject><subject>Porosity</subject><issn>1436-3771</issn><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc1O3TAQhS1UBJT2BbqoLHXDglA7juPcZYtoQUJiQ9fW2JlURkmc2k6lu-HZO5dLf9QFG3us-c4ZjQ9j76S4kEKYj5mOrqlErSqhhagrfcBOZKPaShkjX_1TH7PXOT8IIZvWqCN2rAyVWrQn7PFziD5OC5TgwhjK9py7EMGX8BP5EgvOJcB4TmWK-akNc8_DXDAN4JFeMG5zyNzD6MM68UwuHgryhAuExD1O5JFJwoH3O7uZl9Uhn2KP4xt2OMCY8e3zfcq-fbm6v7yubu--3lx-uq28MrpUDjraTxql9abxZhg6cN45UKbvYNOhFK5WgK52vgVoa2hQG9Ea3TrZKaHUKTvb-y4p_lgxFzuF7HEcYca4ZlubjVYkMYbQD_-hD3FNtCZRnWq02tTtjqr3lKd_yQkHu6QwQdpaKewuHbtPx1I69ikdq0n0_tl6dRP2fyS_4yBA7YFMrfk7pr-zX7D9BShjm8c</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Inada, Rafaela Nanami Handa</creator><creator>Queiroz, Marcela Borsatto</creator><creator>Lopes, Camila Soares</creator><creator>Silva, Evelin Carine Alves</creator><creator>Torres, Fernanda Ferrari Esteves</creator><creator>da Silva, Guilherme Ferreira</creator><creator>Guerreiro-Tanomaru, Juliane Maria</creator><creator>Cerri, Paulo Sérgio</creator><creator>Tanomaru-Filho, Mário</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20230701</creationdate><title>Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model</title><author>Inada, Rafaela Nanami Handa ; Queiroz, Marcela Borsatto ; Lopes, Camila Soares ; Silva, Evelin Carine Alves ; Torres, Fernanda Ferrari Esteves ; da Silva, Guilherme Ferreira ; Guerreiro-Tanomaru, Juliane Maria ; Cerri, Paulo Sérgio ; Tanomaru-Filho, Mário</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-ba80021735594c7ff8abcbba37d8a98e10b23aeb2bc6aa62a4e5706756b183033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Dental restorative materials</topic><topic>Dental sealants</topic><topic>Dentin</topic><topic>Dentistry</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Medicine</topic><topic>Mineralization</topic><topic>Osteocalcin</topic><topic>Porosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inada, Rafaela Nanami Handa</creatorcontrib><creatorcontrib>Queiroz, Marcela Borsatto</creatorcontrib><creatorcontrib>Lopes, Camila Soares</creatorcontrib><creatorcontrib>Silva, Evelin Carine Alves</creatorcontrib><creatorcontrib>Torres, Fernanda Ferrari Esteves</creatorcontrib><creatorcontrib>da Silva, Guilherme Ferreira</creatorcontrib><creatorcontrib>Guerreiro-Tanomaru, Juliane Maria</creatorcontrib><creatorcontrib>Cerri, Paulo Sérgio</creatorcontrib><creatorcontrib>Tanomaru-Filho, Mário</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inada, Rafaela Nanami Handa</au><au>Queiroz, Marcela Borsatto</au><au>Lopes, Camila Soares</au><au>Silva, Evelin Carine Alves</au><au>Torres, Fernanda Ferrari Esteves</au><au>da Silva, Guilherme Ferreira</au><au>Guerreiro-Tanomaru, Juliane Maria</au><au>Cerri, Paulo Sérgio</au><au>Tanomaru-Filho, Mário</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>27</volume><issue>7</issue><spage>3839</spage><epage>3853</epage><pages>3839-3853</pages><issn>1436-3771</issn><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
This study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM).
Materials and methods
Dentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey’s tests (
p
< 0.05).
Results
IRM capsules were thicker and contained greater ICs and IL-6-immunopositive cells at 7 and 15 days. BIOC-R capsules exhibited higher thickness and ICs at 7 days and greater IL-6 at 7 and 15 days than MTAHP (
p
< 0.05). At 30 and 60 days, no significant difference was observed among the groups. OCN-immunopositive cells, von Kossa-positive, and birefringent structures were observed in BIOC-R and MTAHP. MTAHP exhibited higher porosity and interface voids (
p
< 0.05).
Conclusions
BIOC-R, MTAHP, and IRM are biocompatible. Bioceramics materials demonstrate bioactive potential. MTAHP presented the highest porosity and presence of voids.
Clinical relevance
BIOC-R and MTAHP have adequate biological properties. BIOC-R demonstrated lower porosity and presence of voids, which may represent better sealing for its clinical applications.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37014506</pmid><doi>10.1007/s00784-023-05002-5</doi><tpages>15</tpages></addata></record> |
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| issn | 1436-3771 1432-6981 1436-3771 |
| language | eng |
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| source | Springer Nature |
| subjects | Biocompatibility Biological activity Dental restorative materials Dental sealants Dentin Dentistry Inflammation Interleukin 6 Medicine Mineralization Osteocalcin Porosity |
| title | Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model |
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