Individualized luteal phase support using additional oral dydrogesterone in artificially prepared frozen embryo transfer cycles: is it beneficial?

Does additional supplementation with oral dydrogesterone improve reproductive outcomes in patients with low serum progesterone concentrations on the day of frozen embryo transfer (FET) after artificial (HRT) endometrial preparation? Retrospective, single-centre cohort study including 694 unique pati...

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Bibliographic Details
Published in:Reproductive biomedicine online 2023-06, Vol.46 (6), p.939-945
Main Authors: Mackens, Shari, Pais, Francisca, Drakopoulos, Panagiotis, Amghizar, Samah, Roelens, Caroline, Van Landuyt, Lisbet, Tournaye, Herman, De Vos, Michel, Blockeel, Christophe
Format: Article
Language:English
Subjects:
Artificially prepared cycles
Cohort Studies
Dydrogesterone
Embryo Transfer - methods
Female
Frozen embryo transfer
Humans
Individualized luteal phase support
Live birth rate
Luteal Phase
Miscarriage
Pregnancy
Pregnancy Rate
Progesterone
Retrospective Studies
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Summary:Does additional supplementation with oral dydrogesterone improve reproductive outcomes in patients with low serum progesterone concentrations on the day of frozen embryo transfer (FET) after artificial (HRT) endometrial preparation? Retrospective, single-centre cohort study including 694 unique patients performing single blastocyst transfer in an HRT cycle. For luteal phase support, intravaginal micronized vaginal progesterone (MVP, 400 mg twice daily) was administered. Serum progesterone concentrations were assessed prior to FET and outco-mes were compared among patients with normal serum progesterone (≥8.8 ng/ml) continuing the routine protocol and patients with low serum progesterone (
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2023.02.007