Kisspeptin as a predictor of miscarriage: a systematic review

A highly accurate serum marker for predicting viable pregnancy needs to be developed. Recent studies have demonstrated that kisspeptin is a potential biomarker for this purpose. This systematic review evaluated the available data in the literature on the role of kisspeptin as a miscarriage biomarker...

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Published in:The journal of maternal-fetal & neonatal medicine 2023-12, Vol.36 (1), p.2197097-2197097
Main Authors: Silva, Pedro Henrique Alcântara da, Romão, Lourena Guedes de Melo, Freitas, Natércia Paula Alves de, Carvalho, Thiago Ribeiro, Porto, Maria Eduarda Mendes Pontes, Araujo Júnior, Edward, Cavalcante, Marcelo Borges
Format: Article
Language:English
Subjects:
Abortion, Spontaneous
Biomarkers
Female
Fertilization in Vitro
Humans
Infertility
intracytoplasmic sperm injection
in vitro fertilization
Kisspeptin
Kisspeptins
Live Birth
miscarriage
Pregnancy
pregnancy loss
Pregnancy Rate
Reproductive Techniques, Assisted
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Summary:A highly accurate serum marker for predicting viable pregnancy needs to be developed. Recent studies have demonstrated that kisspeptin is a potential biomarker for this purpose. This systematic review evaluated the available data in the literature on the role of kisspeptin as a miscarriage biomarker. A literature search was conducted in the PubMed/Medline, Embase, Web of Science, and Scopus databases using the following keywords: (kisspeptin) AND (miscarriage OR pregnancy loss OR spontaneous abortion OR reproductive failure). Seven case-control studies were selected for the systematic review. The included papers described the potential role of kisspeptin as a putative biomarker of pregnancy loss. Furthermore, two studies reported that changes in kisspeptin levels may be associated with unexplained infertility and low rates of embryo implantation in women undergoing assisted reproductive technology. Kisspeptin might be used as a potential biomarker of pregnancy viability in the near future. However, studies with better evidence are needed to establish the applicability of kisspeptin as a diagnostic and prognostic tool.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2023.2197097