Gingival crevicular fluid galectin-3 and interleukin-1 beta levels in stage 3 periodontitis with grade B and C

Objectives This study aims to evaluate GCF Galectin-3 and Interleukin-1 beta (IL-β) levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in periodontal diseases. Materials and methods A total of 80 systemically healthy...

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Bibliographic Details
Published in:Clinical oral investigations 2023-07, Vol.27 (7), p.3749-3758
Main Authors: Afacan, Beral, Ilhan, Harika Atmaca, Köse, Timur, Emingil, Gülnur
Format: Article
Language:English
Subjects:
Biomarkers
Cytokines
Dental care
Dental health
Dentistry
Galectin-3
Gingivitis
Gum disease
IL-1β
Interleukin 1
Medical diagnosis
Medicine
Periodontal diseases
Periodontics
Periodontitis
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Summary:Objectives This study aims to evaluate GCF Galectin-3 and Interleukin-1 beta (IL-β) levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in periodontal diseases. Materials and methods A total of 80 systemically healthy and non-smoker individuals, 20 stage 3 grade C (S3GC) periodontitis 20 stage 3 grade B (S3GB) periodontitis, 20 gingivitis, and 20 periodontally healthy were enrolled. Clinical periodontal parameters were recorded and GCF Galectin-3 and IL-1β total amounts were measured by ELISA. Receiver operating characteristics curve was used for estimating the area under the curve (AUC). Results Galectin-3 and IL-1β were detected in all participants. Both periodontitis groups had significantly higher GCF Galectin-3 total amounts than periodontally healthy controls ( p
ISSN:1436-3771
1432-6981
1436-3771
DOI:10.1007/s00784-023-04991-7