The prognostic value and biological functions of HFM1 in breast cancer

has been reported to be associated with meiosis and ovarian insufficiency, but its role in tumors remains unknown. This study aims to explore the functions and potential mechanism of in breast cancer. Several databases, protein-protein interactions, gene ontology and the Kyoto Encyclopedia of Genes...

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Bibliographic Details
Published in:Epigenomics 2023-02, Vol.15 (3), p.147-166
Main Authors: Ying, Yingxia, Meng, Yiling, Bian, Lei, Zhang, Meichao, Zhou, Pingting, Zhang, Suning, Wang, Wei, Yao, Yuan, Ren, Qing, Li, Dong
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Hormonal - pharmacology
Antineoplastic Agents, Hormonal - therapeutic use
Breast Neoplasms - pathology
DNA Helicases - genetics
Drug Resistance, Neoplasm - genetics
Female
Humans
Primary Ovarian Insufficiency - genetics
Prognosis
Tamoxifen - therapeutic use
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Summary:has been reported to be associated with meiosis and ovarian insufficiency, but its role in tumors remains unknown. This study aims to explore the functions and potential mechanism of in breast cancer. Several databases, protein-protein interactions, gene ontology and the Kyoto Encyclopedia of Genes and Genomes were used for bioinformatic analysis. Tissue microarrays and cell viability assays were used to detect the expression of HFM1 and tamoxifen resistance, respectively.  was downregulated in breast cancer with poor prognosis and may modulate DNA damage repair pathways and immune infiltration. Moreover, may mediate ovarian steroidogenesis and participate in tamoxifen resistance of estrogen receptor-positive breast cancer cells. We presented a first study on biological functions and potential mechanisms of in cancers.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2023-0041