Crosstalk between phytochemicals and inflammatory signaling pathways

Novel bioactive constituents from natural sources are actively being investigated. The phytochemicals in these phenolic compounds are believed to have a variety of beneficial effects on human health. Several phenolic compounds have been found in plants. The antioxidant potential of phenols has been...

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Bibliographic Details
Published in:Inflammopharmacology 2023-06, Vol.31 (3), p.1117-1147
Main Authors: Prasad, Sonima, Kumar, Vishal, Singh, Charan, Singh, Arti
Format: Article
Language:English
Subjects:
Allergology
Biomedical and Life Sciences
Biomedicine
Cyclooxygenase 2 - metabolism
Dermatology
Gastroenterology
Humans
Immunology
Lipopolysaccharides - pharmacology
Mitogen-Activated Protein Kinases - metabolism
NF-kappa B - metabolism
Nitric Oxide Synthase Type II - metabolism
Pharmacology/Toxicology
Phosphatidylinositol 3-Kinases - metabolism
Phytochemicals - pharmacology
Review
Rheumatology
Signal Transduction
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Summary:Novel bioactive constituents from natural sources are actively being investigated. The phytochemicals in these phenolic compounds are believed to have a variety of beneficial effects on human health. Several phenolic compounds have been found in plants. The antioxidant potential of phenols has been discussed in numerous studies along with their anti-inflammatory effects on pro-inflammatory cytokine, inducible cyclooxygenase-2, and nitric oxide synthase. Through current study, an attempt is made to outline and highlight a wide variety of inflammation-associated signaling pathways that have been modified by several natural compounds. These signaling pathways include nuclear factor-kappa B (NF-кB), activator protein (AP)-1, protein tyrosine kinases (PTKs), mitogen-activated protein kinases (MAPKs), nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factors, tyrosine phosphatidylinositol 3-kinase (PI3K)/AKT, and the ubiquitin–proteasome system. In light of the influence of natural substances on signaling pathways, their impact on the production of inflammatory mediator is highlighted in this review.
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-023-01206-z