MicroRNA expression in osteoarthritis: a meta-analysis

Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases globally, leading to chronic disability and poor prognosis. One of the approaches for optimizing OA treatment is to find early effective diagnostic biomarkers. The contribution of microRNAs (miRNAs) in OA progression is now be...

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Bibliographic Details
Published in:Clinical and experimental medicine 2023-11, Vol.23 (7), p.3737-3749
Main Authors: Liu, Huachen, Yan, Lei, Li, Xiaoke, Li, Dijun, Wang, Guishan, Shen, Nan-Nan, Li, Jiao Jiao, Wang, Bin
Format: Article
Language:English
Subjects:
Arthritis
Biomarkers
Cartilage (articular)
Cartilage diseases
Genomes
Hematology
Internal Medicine
Medicine
Medicine & Public Health
Mesenchymal stem cells
Meta-analysis
MicroRNAs
miRNA
Musculoskeletal diseases
Oncology
Osteoarthritis
Sensitivity analysis
Signal transduction
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Summary:Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases globally, leading to chronic disability and poor prognosis. One of the approaches for optimizing OA treatment is to find early effective diagnostic biomarkers. The contribution of microRNAs (miRNAs) in OA progression is now being increasingly recognized. This review provides a comprehensive summary on studies reporting the expression profiling of miRNAs in OA and associated signaling pathways. We performed a systematic search of the Embase, Web of Science, PubMed, and Cochrane library databases. This systematic review is reported according to the PRISMA checklist. Studies which identified miRNAs with aberrant expression compared to controls during OA progression were included, and a meta-analysis was performed. Results from the random effects model were provided as log10 odds ratios (logORs) and 95% confidence intervals. Sensitivity analysis was conducted to confirm the accuracy of the results. Subgroup analysis was conducted based on tissue source. The target genes of miRNAs identified in this study were extracted from the MiRWalk database, and these target genes were enriched in Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. A total of 191 studies reporting 162 miRNAs were included in our meta-analysis. Among them, 36 miRNAs distributed across 96 studies were expressed in the same direction in at least two studies (13 up-regulated and 23 down-regulated). Subgroup analysis of tissue source revealed that the highest number of studies was conducted using articular cartilage, where the most up-regulated miRNAs were miR-146a-5p (logOR 7.355; P  
ISSN:1591-9528
1591-8890
1591-9528
DOI:10.1007/s10238-023-01063-8