Dietary supplementation with probiotics increases growth performance, improves the intestinal mucosal barrier and activates the Wnt/β‐catenin pathway activity in chicks

Background Probiotics comprise effective feed additives that can replace antibiotics in animal livestock production. However, mono‐strain probiotics appear less effective because of their instability. Therefore, the present study aimed to investigate dietary supplementation with compound probiotics...

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Bibliographic Details
Published in:Journal of the science of food and agriculture 2023-07, Vol.103 (9), p.4649-4659
Main Authors: Tong, Di‐qing, Lu, Zhu‐jin, Zeng, Nan, Wang, Xiu‐qi, Yan, Hui‐chao, Gao, Chun‐qi
Format: Article
Language:English
Subjects:
Absorptivity
Animal Feed - analysis
Animals
Antibiotics
Antigens
beta Catenin - genetics
Catenin
Chickens
chicks
Chlortetracycline
compound probiotics
Cyclin D1
Diamines
Diarrhea
Diarrhea - prevention & control
Diarrhea - veterinary
Diet
Diet - veterinary
Dietary Supplements
Electrical resistivity
Feed additives
Fluorescence
immune function
Immune response
Immunoglobulin G
Immunoglobulin M
intestinal development
Intestine
Jejunum
Juveniles
Livestock
Livestock production
Molecular modelling
Mucosa
Myc protein
Probiotics
Proliferating cell nuclear antigen
Signal transduction
Signaling
Small intestine
Stem cells
Wnt protein
Wnt Signaling Pathway
Wnt/β‐catenin
Yeasts
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Summary:Background Probiotics comprise effective feed additives that can replace antibiotics in animal livestock production. However, mono‐strain probiotics appear less effective because of their instability. Therefore, the present study aimed to investigate dietary supplementation with compound probiotics (CPP) on growth performance, diarrhea rate and intestinal mucosal barrier, as well as the possible molecular mechanism, in chicks. In total, 360 1‐day‐old chicks of the Hy‐Line Brown Chicks were randomly divided into the control group (CON, basal diet), chlortetracycline group (500 mg kg−1 CTC) and compound probiotics group (1000 mg kg−1 CPP, consisting of Bacillus subtilis, Bacillus licheniformis, Enterococcus faecium and yeast). The experiment period was 56 days. Results The results showed that, in comparison with the CON group, CPP significantly increased the average daily feed intake and average daily gain of chicks and reduced diarrhea (P 
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.12562