Serum IgG of patients with relapsing inflammatory optic neuropathy immunoreacts with Sox2-positive glial cells of the optic nerve

•RION patients may have antibodies to interfascicular cells of the optic nerve.•Binding sites of these antibodies co-localize with those of Sox2-antibody.•A subset of RION may be characterized with anti-glial antibodies. Given the significance of glial cells in maintenance of neurons, antibodies dir...

Full description

Saved in:
Bibliographic Details
Published in:Multiple sclerosis and related disorders 2023-05, Vol.73, p.104694-104694, Article 104694
Main Authors: Erdağ, Ece, Emekli, Ahmet Serkan, Gündüz, Tuncay, Küçükali, Cem İsmail, Kürtüncü, Murat, Tüzün, Erdem
Format: Article
Language:English
Subjects:
Antibody
Autoimmunity
Glia
Optic neuritis
Sox2
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•RION patients may have antibodies to interfascicular cells of the optic nerve.•Binding sites of these antibodies co-localize with those of Sox2-antibody.•A subset of RION may be characterized with anti-glial antibodies. Given the significance of glial cells in maintenance of neurons, antibodies directed against glial cells of the optic nerve might reasonably be expected to have a pathogenic impact in relapsing inflammatory optic neuropathy (RION). We investigated IgG immunoreactive with the optic nerve tissue by indirect immunohistochemistry using sera of 20 RION patients. Commercial Sox2-antibody was used for double immunolabeling. Serum IgG of 5 RION patients reacted with cells aligned in the interfascicular regions of the optic nerve. IgG binding sites significantly co-localized with the Sox2-antibody. Our results suggest that a subset of RION patients may harbor anti-glial antibodies.
ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2023.104694