Predictive utility of the fetal cerebroplacental ratio for hypoxic ischaemic encephalopathy, severe neonatal morbidity and perinatal mortality in late‐preterm and term infants

Aims The aim of this study was to evaluate the association of a low cerebroplacental ratio (CPR) with hypoxic ischaemic encephalopathy (HIE), severe neonatal morbidity (SNM) and perinatal mortality (PNM). Methods This was a retrospective cohort study of late‐preterm and term births at Mater Mothers’...

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Published in:Australian & New Zealand journal of obstetrics & gynaecology 2023-08, Vol.63 (4), p.491-498
Main Authors: Bendall, Alexa, Schreiber, Veronika, Crawford, Kylie, Kumar, Sailesh
Format: Article
Language:English
Subjects:
cerebroplacental ratio
fetal growth restriction
hypoxic ischaemic encephalopathy
perinatal mortality
severe neonatal morbidity
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Summary:Aims The aim of this study was to evaluate the association of a low cerebroplacental ratio (CPR) with hypoxic ischaemic encephalopathy (HIE), severe neonatal morbidity (SNM) and perinatal mortality (PNM). Methods This was a retrospective cohort study of late‐preterm and term births at Mater Mothers’ Hospital, Brisbane, between 2016 and 2020. Study outcomes were HIE, PNM and SNM (a composite of severe acidosis, Apgar score less than four at 5 min, severe respiratory distress or need for significant cardiopulmonary resuscitation at birth). Univariate and multivariable logistic regressions were used to determine if a low CPR was associated with HIE, SNM or PNM. Results A total of 51 870 births met the inclusion criteria. Of these, 216 (0.42%) were complicated by HIE, 10 224 (19.7%) had SNM and 251 (0.48%) had PNM. Rates of low CPR (
ISSN:0004-8666
1479-828X
DOI:10.1111/ajo.13668