Design and Development of Inexpensive Paper-Based Chemosensors for Detection of Divalent Copper

Simple, portable, and low-cost paper-based sensors are alternative devices that have the potential to replace high-cost sensing technologies. The compatibility of the paper base biosensors for both chemical and biochemical accentuates its feasibility for application in clinical diagnosis, environmen...

Full description

Saved in:
Bibliographic Details
Published in:Journal of fluorescence 2023-11, Vol.33 (6), p.2327-2338
Main Authors: Geetha, Mithra, Sadasivuni, Kishor Kumar, Al-Ejji, Maryam, Sivadas, Nandagopal, Bhattacharyya, Bagmita, Musthafa, Farzana N., Alfarwati, Sarya, Promi, Tamanna Jannat, Ahmad, Sumayya Ali, Alabed, Sara, Hijazi, Dima Anwar, Alsaedi, Fatimatulzahraa, Al-Shaibah, Faozia Nasser
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedicine
Biophysics
Biosensors
Biotechnology
Calcium ions
Cations
Chemical sensors
Chemoreceptors
Copper
Copper chloride
Dyes
Environmental monitoring
Interference
Portable equipment
Selectivity
Sensors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Simple, portable, and low-cost paper-based sensors are alternative devices that have the potential to replace high-cost sensing technologies. The compatibility of the paper base biosensors for both chemical and biochemical accentuates its feasibility for application in clinical diagnosis, environmental monitoring, and food quality monitoring. High concentration of copper in blood serum and urine is associated with diseases like liver diseases, carcinomas, acute and chronic infections, rheumatoid arthritis, etc. Detection of copper concentration can give an early sign of Alzheimer disease. Apart from that genetic Wilson's disease can be detected by evaluating the concentration of copper in the urine. In view of the above advantages, a novel and the highly sensitive paper-based sensor has been designed for the selective detection of Cu 2+ ions. The fast and highly sensitive chemiresistive multi-dye system sensor can detect Cu 2+ ions selectively in as low as 2.23 ppm concentration. Least interference has been observed for counter ion in the detection of Cu 2+ . Copper chloride, nitrate, and acetate were used to validate the detection process. This assay provides a very high selectivity of Cu 2+ ion over other metal cations such as Na + , Mg 2+ , Ca 2+ , etc. The easy preparation and high stability of dye solutions, easy functionalization of the paper-based sensors, high selectivity over other cations, low interference of counter anion, and significantly low detection limit of 2.23 ppm make it an effective Cu 2+ ion sensor for real-time application in near future. Graphical Abstract
ISSN:1053-0509
1573-4994
DOI:10.1007/s10895-023-03220-4