Word of caution: Rectal cancer without response to neoadjuvant treatment - Do not wait for surgery

We hypothesized that prolonging the interval to surgery in non-responders to neoadjuvant chemoradiation therapy (nCRT) could lead to worse oncologic outcomes. Rectal adenocarcinoma patients with poor tumor response to nCRT (AJCC tumor regression grade 3) were selected. Oncologic outcomes were evalua...

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Bibliographic Details
Published in:The American journal of surgery 2023-10, Vol.226 (4), p.548-552
Main Authors: Duraes, Leonardo C., Kalady, Matthew F., Liska, David, Gorgun, Emre, Kessler, Hermann, Otero-Pineiro, Ana, Steele, Scott R., Valente, Michael A.
Format: Article
Language:English
Subjects:
Adenocarcinoma
AJCC
Cancer
Cancer therapies
Chemoradiotherapy
Chemotherapy
Clinical outcomes
Colorectal cancer
Hospitals
Length of stay
Morbidity
Mortality
Neoadjuvant chemoradiation
Outcomes
Patients
Radiation response
Radiation therapy
Rectal cancer
Rectum
Surgery
Survival
Tumors
Variables
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Summary:We hypothesized that prolonging the interval to surgery in non-responders to neoadjuvant chemoradiation therapy (nCRT) could lead to worse oncologic outcomes. Rectal adenocarcinoma patients with poor tumor response to nCRT (AJCC tumor regression grade 3) were selected. Oncologic outcomes were evaluated according to the time interval between completion of nCRT and surgery. Among 56 non-responders, 28 patients surgically treated ≥8 weeks after completion of nCRT had worse disease-free survival (31% vs. 49%, p = 0.05) and worse overall survival (34% vs. 53%, p = 0.02) compared to patients
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2023.03.021