Rubochingosides A - J, labdane-type diterpene glycosides from leaves of Rubus chingii

Ten previously undescribed labdane-type triterpenoids, rubochingosides A - J (1–10), were isolated from the leaves of Rubus chingii Hu. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxicity of all isolated compounds was tested against five human tumor cell lines (B...

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Published in:Phytochemistry (Oxford) 2023-06, Vol.210, p.113670-113670, Article 113670
Main Authors: Wang, Jianxiong, Xiao, Xiaowu, Zhou, Nian, Zhao, Minmin, Lang, Shuqin, Ren, Qi, Wang, Dong, Fu, Huizheng
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Cytotoxic activities
Diterpene glycosides
Diterpenes - analysis
Diterpenes - pharmacology
Female
Glycosides - chemistry
Humans
Molecular Structure
Ovarian Neoplasms
Plant Leaves - chemistry
Rosaceae
Rubochingosides A - J
Rubus - chemistry
Rubus chingii
Structure elucidation
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Summary:Ten previously undescribed labdane-type triterpenoids, rubochingosides A - J (1–10), were isolated from the leaves of Rubus chingii Hu. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxicity of all isolated compounds was tested against five human tumor cell lines (Bel-7402, Caski, BGC-823, A2780, and HCT-116). Among them, compounds 4 and 8 showed cytotoxic activities against Bel-7402 and A2780 cells with IC50 values of 10.43 ± 0.51 and 29.03 ± 2.94 μM, respectively; Compound 8 exhibited cytotoxic activities against Bel-7402 and HCT-116 cells with IC50 values of 17.78 ± 1.54 and 26.23 ± 6.14 μM, respectively. Ten previously undescribed labdane-type triterpenoids, rubochingosides A - J (1–10), were isolated from the leaves of Rubus chingii Hu. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxicity of all isolated compounds was tested against five human tumor cell lines (Bel-7402, Caski, BGC-823, A2780, and HCT-116). Among them, compounds 4 and 8 showed cytotoxic activities against Bel-7402 and A2780 cells with IC50 values of 10.43 ± 0.51 and 29.03 ± 2.94 μM, respectively; Compound 8 exhibited cytotoxic activities against Bel-7402 and HCT-116 cells with IC50 values of 17.78 ± 1.54 and 26.23 ± 6.14 μM, respectively. [Display omitted] •The chemical composition of the genus Rubus was enriched.•Ten previously undescribed labdane-type diterpenes were isolated from the leaves of Rubus chingii.•Two compounds were found to have moderate to potent anti-tumor activity.
ISSN:0031-9422
1873-3700
DOI:10.1016/j.phytochem.2023.113670