Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies

Hematopoiesis is maintained and regulated by a bone marrow-specific microenvironment called a niche. In hematological malignancies, tumor cells induce niche remodeling, and the reconstructed niche is closely linked to disease pathogenesis. Recent studies have suggested that extracellular vesicles (E...

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Bibliographic Details
Published in:International journal of hematology 2023-06, Vol.117 (6), p.821-829
Main Authors: Hayashi, Yasutaka, Nishimura, Koutarou, Tanaka, Atsushi, Inoue, Daichi
Format: Article
Language:English
Subjects:
Biomedical research
Bone marrow
Bone Marrow - pathology
Bone remodeling
Chemotherapy
Extracellular vesicles
Extracellular Vesicles - pathology
Hematologic Neoplasms - pathology
Hematology
Hematopoiesis
Hemopoiesis
Humans
Malignancy
Medicine
Medicine & Public Health
Metabolism
Microenvironments
Mutation
Myeloproliferative Disorders - pathology
Oncology
Pathogenesis
Progress in Hematology
Roles
Stem cells
Therapeutic targets
Tumor cells
Tumor Microenvironment
Tumors
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Summary:Hematopoiesis is maintained and regulated by a bone marrow-specific microenvironment called a niche. In hematological malignancies, tumor cells induce niche remodeling, and the reconstructed niche is closely linked to disease pathogenesis. Recent studies have suggested that extracellular vesicles (EVs) secreted from tumor cells play a principal role in niche remodeling in hematological malignancies. Although EVs are emerging as potential therapeutic targets, the underlying mechanism of action remains unclear, and selective inhibition remains a challenge. This review summarizes remodeling of the bone marrow microenvironment in hematological malignancies and its contribution to pathogenesis, as well as roles of tumor-derived EVs, and provides a perspective on future research in this field.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-023-03587-x