Effect of Hypoalbuminemia in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism

Objectives Treatment for primary hyperparathyroidism is parathyroidectomy. This study identifies the association between hypoalbuminemia (HA) and outcomes in patients undergoing parathyroidectomy for primary hyperparathyroidism. Methods This retrospective cohort analysis utilized the 2006–2015 Natio...

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Published in:The Laryngoscope 2023-08, Vol.133 (8), p.2035-2039
Main Authors: Khawaja, Imran M., Randhawa, Avneet, Randhawa, Karandeep, Aftab, Owais M., Patel, Roshan V., Eloy, Jean Anderson, Fang, Christina H.
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Language:English
Subjects:
hyperparathyroidism
hypoalbuminemia
Laryngoscopy
NSQIP
nutrition
parathyroidectomy
Regression analysis
Terminology
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container_issue 8
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container_title The Laryngoscope
container_volume 133
creator Khawaja, Imran M.
Randhawa, Avneet
Randhawa, Karandeep
Aftab, Owais M.
Patel, Roshan V.
Eloy, Jean Anderson
Fang, Christina H.
description Objectives Treatment for primary hyperparathyroidism is parathyroidectomy. This study identifies the association between hypoalbuminemia (HA) and outcomes in patients undergoing parathyroidectomy for primary hyperparathyroidism. Methods This retrospective cohort analysis utilized the 2006–2015 National Surgical Quality Improvement Program database. Current Procedure Terminology codes were used to identify patients undergoing parathyroidectomy for primary hyperparathyroidism. Prolonged length of stay (LOS) was defined as a duration of 2 days or greater. Demographics and comorbidities were compared between HA (serum albumin
doi_str_mv 10.1002/lary.30691
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This study identifies the association between hypoalbuminemia (HA) and outcomes in patients undergoing parathyroidectomy for primary hyperparathyroidism. Methods This retrospective cohort analysis utilized the 2006–2015 National Surgical Quality Improvement Program database. Current Procedure Terminology codes were used to identify patients undergoing parathyroidectomy for primary hyperparathyroidism. Prolonged length of stay (LOS) was defined as a duration of 2 days or greater. Demographics and comorbidities were compared between HA (serum albumin <3.5 g/dL) and non‐HA cohorts using chi‐square analysis. The independent effect of HA on adverse outcomes was analyzed using binary logistic regression. Results A total of 7183 cases with primary hyperparathyroidism were classified into HA (n = 381) and non‐HA (n = 6802) cohorts. HA patients had increased complications, including renal insufficiency (0.8% vs. 0.0%, p = 0.001), sepsis (1.0% vs. 0.1%, p = 0.003), pneumonia (0.8% vs. 0.1%, p = 0.018), acute renal failure (1.0% vs. 0.0%, p < 0.001), and unplanned intubation (1.3% vs. 0.2%, p = 0.004). HA patients had increased risk of death (1.6% vs. 0.1%, p < 0.001), prolonged LOS (40.9% vs. 6.3%, p < 0.001), and any complication (5.5% vs. 1.2%, p < 0.001). Adjusted binary logistic regression indicated HA patients experienced increased odds of progressive renal insufficiency (OR 18.396, 95% CI 1.844–183.571, p = 0.013), prolonged LOS (OR 4.892; 95% CI 3.571–6.703; p < 0.001), unplanned reoperation (OR 2.472; 95% CI 1.012–6.035; p = 0.047), and unplanned readmission (OR 3.541; 95% CI 1.858–6.748; p < 0.001). Conclusions HA may be associated with adverse complications in patients undergoing parathyroidectomy for primary hyperparathyroidism. Level of Evidence 3 Laryngoscope, 133:2035–2039, 2023]]></description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.30691</identifier><identifier>PMID: 37042551</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>hyperparathyroidism ; hypoalbuminemia ; Laryngoscopy ; NSQIP ; nutrition ; parathyroidectomy ; Regression analysis ; Terminology</subject><ispartof>The Laryngoscope, 2023-08, Vol.133 (8), p.2035-2039</ispartof><rights>2023 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3571-5e0f2e698dbf62f0ee8b1722a0994f6121c37467d0af29fcc349816f21d675893</citedby><cites>FETCH-LOGICAL-c3571-5e0f2e698dbf62f0ee8b1722a0994f6121c37467d0af29fcc349816f21d675893</cites><orcidid>0000-0002-0013-9040 ; 0009-0001-6691-3131 ; 0000-0001-6804-6062 ; 0000-0003-4148-119X ; 0000-0001-6047-2788</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37042551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khawaja, Imran M.</creatorcontrib><creatorcontrib>Randhawa, Avneet</creatorcontrib><creatorcontrib>Randhawa, Karandeep</creatorcontrib><creatorcontrib>Aftab, Owais M.</creatorcontrib><creatorcontrib>Patel, Roshan V.</creatorcontrib><creatorcontrib>Eloy, Jean Anderson</creatorcontrib><creatorcontrib>Fang, Christina H.</creatorcontrib><title>Effect of Hypoalbuminemia in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description><![CDATA[Objectives Treatment for primary hyperparathyroidism is parathyroidectomy. This study identifies the association between hypoalbuminemia (HA) and outcomes in patients undergoing parathyroidectomy for primary hyperparathyroidism. Methods This retrospective cohort analysis utilized the 2006–2015 National Surgical Quality Improvement Program database. Current Procedure Terminology codes were used to identify patients undergoing parathyroidectomy for primary hyperparathyroidism. Prolonged length of stay (LOS) was defined as a duration of 2 days or greater. Demographics and comorbidities were compared between HA (serum albumin <3.5 g/dL) and non‐HA cohorts using chi‐square analysis. The independent effect of HA on adverse outcomes was analyzed using binary logistic regression. Results A total of 7183 cases with primary hyperparathyroidism were classified into HA (n = 381) and non‐HA (n = 6802) cohorts. HA patients had increased complications, including renal insufficiency (0.8% vs. 0.0%, p = 0.001), sepsis (1.0% vs. 0.1%, p = 0.003), pneumonia (0.8% vs. 0.1%, p = 0.018), acute renal failure (1.0% vs. 0.0%, p < 0.001), and unplanned intubation (1.3% vs. 0.2%, p = 0.004). HA patients had increased risk of death (1.6% vs. 0.1%, p < 0.001), prolonged LOS (40.9% vs. 6.3%, p < 0.001), and any complication (5.5% vs. 1.2%, p < 0.001). Adjusted binary logistic regression indicated HA patients experienced increased odds of progressive renal insufficiency (OR 18.396, 95% CI 1.844–183.571, p = 0.013), prolonged LOS (OR 4.892; 95% CI 3.571–6.703; p < 0.001), unplanned reoperation (OR 2.472; 95% CI 1.012–6.035; p = 0.047), and unplanned readmission (OR 3.541; 95% CI 1.858–6.748; p < 0.001). Conclusions HA may be associated with adverse complications in patients undergoing parathyroidectomy for primary hyperparathyroidism. Level of Evidence 3 Laryngoscope, 133:2035–2039, 2023]]></description><subject>hyperparathyroidism</subject><subject>hypoalbuminemia</subject><subject>Laryngoscopy</subject><subject>NSQIP</subject><subject>nutrition</subject><subject>parathyroidectomy</subject><subject>Regression analysis</subject><subject>Terminology</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUQIMozvjY-AFScCNCNY8maZYy-IIBRRR0FdI2GSNtU5MW6d-bsT7AhatAcnK49wBwgOApghCf1cqPpwQygTbAHFGC0kwIugnm8ZGkOcVPM7ATwiuEiBMKt8GMcJhhStEcFBfG6LJPnEmux86puhga2-rGqsS2yZ3qrW77kDy2lfYrZ9tVvPOqfxm9s1X86JoxMc4nd942cYy1RPvuF7Gh2QNbRtVB73-du-Dx8uJhcZ0ub69uFufLtCSUo5RqaLBmIq8Kw7CBWucF4hgrKERmGMKoJDxjvILKYGHKkmQiR8xgVDFOc0F2wfHk7bx7G3ToZWNDqetatdoNQeI8Bsg4JySiR3_QVzf4Nk4XKUJzyAjLInUyUaV3IXhtZDdtKRGU6_JyXV5-lo_w4ZdyKBpd_aDfqSOAJuDd1nr8RyWX5_fPk_QD2saO1A</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Khawaja, Imran M.</creator><creator>Randhawa, Avneet</creator><creator>Randhawa, Karandeep</creator><creator>Aftab, Owais M.</creator><creator>Patel, Roshan V.</creator><creator>Eloy, Jean Anderson</creator><creator>Fang, Christina H.</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0013-9040</orcidid><orcidid>https://orcid.org/0009-0001-6691-3131</orcidid><orcidid>https://orcid.org/0000-0001-6804-6062</orcidid><orcidid>https://orcid.org/0000-0003-4148-119X</orcidid><orcidid>https://orcid.org/0000-0001-6047-2788</orcidid></search><sort><creationdate>202308</creationdate><title>Effect of Hypoalbuminemia in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism</title><author>Khawaja, Imran M. ; Randhawa, Avneet ; Randhawa, Karandeep ; Aftab, Owais M. ; Patel, Roshan V. ; Eloy, Jean Anderson ; Fang, Christina H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3571-5e0f2e698dbf62f0ee8b1722a0994f6121c37467d0af29fcc349816f21d675893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>hyperparathyroidism</topic><topic>hypoalbuminemia</topic><topic>Laryngoscopy</topic><topic>NSQIP</topic><topic>nutrition</topic><topic>parathyroidectomy</topic><topic>Regression analysis</topic><topic>Terminology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khawaja, Imran M.</creatorcontrib><creatorcontrib>Randhawa, Avneet</creatorcontrib><creatorcontrib>Randhawa, Karandeep</creatorcontrib><creatorcontrib>Aftab, Owais M.</creatorcontrib><creatorcontrib>Patel, Roshan V.</creatorcontrib><creatorcontrib>Eloy, Jean Anderson</creatorcontrib><creatorcontrib>Fang, Christina H.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khawaja, Imran M.</au><au>Randhawa, Avneet</au><au>Randhawa, Karandeep</au><au>Aftab, Owais M.</au><au>Patel, Roshan V.</au><au>Eloy, Jean Anderson</au><au>Fang, Christina H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Hypoalbuminemia in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>2023-08</date><risdate>2023</risdate><volume>133</volume><issue>8</issue><spage>2035</spage><epage>2039</epage><pages>2035-2039</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract><![CDATA[Objectives Treatment for primary hyperparathyroidism is parathyroidectomy. This study identifies the association between hypoalbuminemia (HA) and outcomes in patients undergoing parathyroidectomy for primary hyperparathyroidism. Methods This retrospective cohort analysis utilized the 2006–2015 National Surgical Quality Improvement Program database. Current Procedure Terminology codes were used to identify patients undergoing parathyroidectomy for primary hyperparathyroidism. Prolonged length of stay (LOS) was defined as a duration of 2 days or greater. Demographics and comorbidities were compared between HA (serum albumin <3.5 g/dL) and non‐HA cohorts using chi‐square analysis. The independent effect of HA on adverse outcomes was analyzed using binary logistic regression. Results A total of 7183 cases with primary hyperparathyroidism were classified into HA (n = 381) and non‐HA (n = 6802) cohorts. HA patients had increased complications, including renal insufficiency (0.8% vs. 0.0%, p = 0.001), sepsis (1.0% vs. 0.1%, p = 0.003), pneumonia (0.8% vs. 0.1%, p = 0.018), acute renal failure (1.0% vs. 0.0%, p < 0.001), and unplanned intubation (1.3% vs. 0.2%, p = 0.004). HA patients had increased risk of death (1.6% vs. 0.1%, p < 0.001), prolonged LOS (40.9% vs. 6.3%, p < 0.001), and any complication (5.5% vs. 1.2%, p < 0.001). Adjusted binary logistic regression indicated HA patients experienced increased odds of progressive renal insufficiency (OR 18.396, 95% CI 1.844–183.571, p = 0.013), prolonged LOS (OR 4.892; 95% CI 3.571–6.703; p < 0.001), unplanned reoperation (OR 2.472; 95% CI 1.012–6.035; p = 0.047), and unplanned readmission (OR 3.541; 95% CI 1.858–6.748; p < 0.001). Conclusions HA may be associated with adverse complications in patients undergoing parathyroidectomy for primary hyperparathyroidism. Level of Evidence 3 Laryngoscope, 133:2035–2039, 2023]]></abstract><cop>Hoboken, USA</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>37042551</pmid><doi>10.1002/lary.30691</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0013-9040</orcidid><orcidid>https://orcid.org/0009-0001-6691-3131</orcidid><orcidid>https://orcid.org/0000-0001-6804-6062</orcidid><orcidid>https://orcid.org/0000-0003-4148-119X</orcidid><orcidid>https://orcid.org/0000-0001-6047-2788</orcidid></addata></record>
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subjects hyperparathyroidism
hypoalbuminemia
Laryngoscopy
NSQIP
nutrition
parathyroidectomy
Regression analysis
Terminology
title Effect of Hypoalbuminemia in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism
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