Morphofunctional Properties of Spindle-Shaped Platelets

Morphofunctional properties of spindle-shaped platelets under normal and pathological conditions were studied by the method based on vital staining. In donor blood and plasma isolated by centrifugation at 300 g , no spindle-shaped platelets were detected; after centrifugation at 3000 g , spindle-sha...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-03, Vol.174 (5), p.681-684
Main Author: Makarov, M. S.
Format: Article
Language:English
Subjects:
Analysis
Biomedical and Life Sciences
Biomedicine
Blood Platelets
Blood Preservation
Cell Biology
Centrifugation
Cytoplasm
Cytoskeleton
Emergency medical care
Ethylenediaminetetraacetic acid
Fractures
Functional morphology
Humans
Internal Medicine
Laboratory Medicine
Medicine
Morphology
Pathology
Physiology
Plasma
Platelets
Poisoning
Trauma
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Summary:Morphofunctional properties of spindle-shaped platelets under normal and pathological conditions were studied by the method based on vital staining. In donor blood and plasma isolated by centrifugation at 300 g , no spindle-shaped platelets were detected; after centrifugation at 3000 g , spindle-shaped platelets were detected in a small amount in 20% samples. During plasma storage at 20-22°C, spindle-shaped platelets appeared after 1-2 days, after 3 days their number increased to 30% and higher. Spindle-shaped platelets contained a small number of granules and did not exhibit active adhesion, while the structure of their membranes was normal after 1-2 days of storage and abnormalities appeared during subsequent storage. Spindle-shaped platelets were found in the blood of patients with acute exogenous poisoning and severe thermal trauma. Spindle-shaped platelets can be used as an additional criterion for assessing the quality of the platelet population.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05769-3