A Self-Healing Multifunctional Hydrogel System Accelerates Diabetic Wound Healing through Orchestrating Immunoinflammatory Microenvironment

Developing an effective treatment strategy of drug delivery to improve diabetic wound healing remains a major challenge in clinical practice nowadays, due to multidrug-resistant bacterial infections, angiopathy, and oxidative damage in the wound microenvironment. Herein, an effective and convenient...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2023-04, Vol.15 (16), p.19847-19862
Main Authors: Hao, Zhichao, Liu, Gen, Ren, Lin, Liu, Jiangchen, Liu, Chuanzi, Yang, Tao, Wu, Xiangnan, Zhang, Xinchun, Yang, Ling, Xia, Juan, Li, Weichang
Format: Article
Language:English
Subjects:
Aldehydes
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Biological and Medical Applications of Materials and Interfaces
Catechols - pharmacology
Diabetes Mellitus
Hydrogels - pharmacology
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Summary:Developing an effective treatment strategy of drug delivery to improve diabetic wound healing remains a major challenge in clinical practice nowadays, due to multidrug-resistant bacterial infections, angiopathy, and oxidative damage in the wound microenvironment. Herein, an effective and convenient strategy was designed through a self-healing multiple-dynamic-bond cross-linked hydrogel with interpenetrating networks, which was formed by multiple-dynamic-bond cross-linking of reversible catechol-Fe3+ coordinate bonds, hydrogen bonding, and Schiff base bonds. The excellent autonomous healing of the hydrogel was initiated and accelerated by Schiff bonds with reversible breakage between 3,4-dihydroxybenzaldehyde containing catechol and aldehyde groups and chitosan chains, and further consolidated by the co-optation of other noncovalent interactions contributed of hydrogen bonding and Fe3+ coordinate bonds. Intriguingly, cathelicidin LL-37 was introduced and uniformly dispersed in the dynamic interpenetrating networks of the hydrogel as a bioactive molecular to orchestrate the diabetic wound healing microenvironment. This multifunctional wound dressing can significantly promote diabetic wound healing by antibacterial activity, immunomodulation, anti-inflammation, neovascularization, and antioxidant activity. Therefore, this study provided an effective and safe strategy for guiding the diabetic wound treatment in clinical applications.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.2c23323