Testosterone or dihydrotestosterone: what should be evaluated in hirsutism?

Purpose Dihydrotestosterone is a more potent androgen derived from testosterone and androstenediones, but its measurement has not been routinely recommended in women with hirsutism, and there is limited information in this regard with equivocal findings. This study aimed to evaluate serum dihydrotes...

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Bibliographic Details
Published in:Irish journal of medical science 2023-12, Vol.192 (6), p.2823-2827
Main Authors: Darjani, Abbas, Alizadeh, Narges, Gharaei Nejad, Kaveh, Eftekhari, Hojat, Rafiei, Rana, Kazemi, Hasan, Rafiei, Elahe
Format: Article
Language:English
Subjects:
Family Medicine
General Practice
Internal Medicine
Medicine
Medicine & Public Health
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Summary:Purpose Dihydrotestosterone is a more potent androgen derived from testosterone and androstenediones, but its measurement has not been routinely recommended in women with hirsutism, and there is limited information in this regard with equivocal findings. This study aimed to evaluate serum dihydrotestosterone level in patients with hirsutism compared to women without hirsutism. Methods In this case–control study (during 2021–2022), serum levels of total testosterone, free testosterone, and dihydrotestosterone were evaluated in 101 women with hirsutism and 101 healthy women. Hormonal levels were measured with chemiluminescent immunoassay method. Age and hormonal levels in each group, body mass index, menstrual status, complaint of decreased scalp hair density, and ovarian ultrasound findings in hirsutism group were collected and analyzed. Results There was significant difference in free testosterone and dihydrotestosterone levels ( P  
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-023-03366-x