Conformation transitions of blood proteins under influence of physical factors on microwave dielectric method

In this article, the influence of γ-irradiation and temperature on albumin and fibrinogen conformation and dielectric properties of protein solutions have been studied by the microwave dielectric method. Both the values of the real part ε′ (dielectric permittivity) and the imaginary part ε″ (dielect...

Full description

Saved in:
Bibliographic Details
Published in:Journal of quantitative spectroscopy & radiative transfer 2006-11, Vol.102 (1), p.18-24
Main Authors: Gorobchenko, O.A., Nikolov, O.T., Gatash, S.V.
Format: Article
Language:English
Subjects:
Conformation
Dielectric permittivity
Dielectric properties
Dielectrics
Fibrinogen
Hydration
Microwave dielectric method
Microwaves
Permittivity
Proteins
Serum albumin
γ-irradiation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this article, the influence of γ-irradiation and temperature on albumin and fibrinogen conformation and dielectric properties of protein solutions have been studied by the microwave dielectric method. Both the values of the real part ε′ (dielectric permittivity) and the imaginary part ε″ (dielectric losses) of the complex dielectric permittivity of the aqueous solution of bovine serum albumin and human fibrinogen as functions of temperature and γ-irradiation dose have been obtained. The time of dielectric relaxation of water molecules in the protein solutions was calculated. The hydration of the albumin and fibrinogen molecules was determined. The temperature dependencies of hydration are non-monotonous and have a number of characteristic features at the temperatures 30–34 and 44–47 °C for serum albumin, and 24 and 32 °C for fibrinogen.
ISSN:0022-4073
1879-1352
DOI:10.1016/j.jqsrt.2006.02.063