Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation

Current guidelines for aortic regurgitation (AR) recommend the same linear left ventricular (LV) dimension for intervention regardless of age and sex. The purpose of this study was to evaluate the impact of age and sex on the degree of LV remodeling and outcomes. We included consecutive patients wit...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2023-04, Vol.81 (15), p.1474-1487
Main Authors: Akintoye, Emmanuel, Saijo, Yoshihito, Braghieri, Lorenzo, Badwan, Osamah, Patel, Hardik, Dabbagh, M Marwan, El Dahdah, Joseph, Jellis, Christine L., Desai, Milind Y., Rodriguez, L. Leonardo, Grimm, Richard A., Griffin, Brian P., Popović, Zoran B.
Format: Article
Language:English
Subjects:
Adult
age
Aged
aortic regurgitation
Aortic Valve Insufficiency - diagnostic imaging
Echocardiography
Female
Humans
Male
Middle Aged
remodeling
Retrospective Studies
sex
Stroke Volume
Ventricular Function, Left
Ventricular Remodeling
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Summary:Current guidelines for aortic regurgitation (AR) recommend the same linear left ventricular (LV) dimension for intervention regardless of age and sex. The purpose of this study was to evaluate the impact of age and sex on the degree of LV remodeling and outcomes. We included consecutive patients with severe AR who were serially monitored by echocardiogram between 2010 and 2016. The 2 main endpoints were as follows: 1) LV end-systolic volume indexed to body surface area (LVESVi) and LV end-diastolic volume indexed to body surface area; and 2) adverse events (AE). We evaluated the longitudinal rate of LV remodeling and determined the association between LV volume and AE by age and sex. A total of 525 adult patients (26% women) with a median echocardiogram follow-up of 2.0 years (IQR: 1.0-3.6 years) were included. At baseline, older patients (age ≥60 years) had smaller LV volumes compared with younger patients (age 
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2023.02.037