A Cheap and Efficient Oxidant (n‑Bu)4NNO3‑Enabled C(sp2)– and C(sp3)–H Olefination at Room Temperature

To further promote the widely practical application of C–H activation, developing green and mild reaction conditions has invariably been the objective of researchers, especially when it comes to remote C–H activation reactions. Herein, we report a new cheap and powerful (n-Bu)4NNO3 oxidant. This oxi...

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Bibliographic Details
Published in:Organic letters 2023-04, Vol.25 (15), p.2622-2626
Main Authors: Gu, Cheng-Hao, Zhang, Zhen, Shen, Shuo-Jie, Xu, Hua-Jin, Hu, Yi
Format: Article
Language:English
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Summary:To further promote the widely practical application of C–H activation, developing green and mild reaction conditions has invariably been the objective of researchers, especially when it comes to remote C–H activation reactions. Herein, we report a new cheap and powerful (n-Bu)4NNO3 oxidant. This oxidant is efficient and universal for Pd­(II)-catalyzed sp2 and sp3 C–H olefination and allows the reaction to be carried out at room temperature. Because of this, we attempted to make C–H functionalization more economical and environmentally benign.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00621