Insight into the transcription factors regulating Ischemic stroke and glioma in response to shared stimuli

Cerebral ischemic stroke and glioma are the two leading causes of patient mortality globally. Despite physiological variations, 1 in 10 people who have an ischemic stroke go on to develop brain cancer, most notably gliomas. In addition, glioma treatments have also been shown to increase the risk of...

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Published in:Seminars in cancer biology 2023-07, Vol.92, p.102-127
Main Authors: Waseem, Arshi, Rashid, Summya, Rashid, Khalid, Khan, Mohsin Ali, Khan, Rehan, Haque, Rizwanul, Seth, Pankaj, Raza, Syed Shadab
Format: Article
Language:English
Subjects:
Blood-tumor barrier
Brain Neoplasms - complications
Brain Neoplasms - genetics
Cancer
Glioma
Glioma - complications
Glioma - genetics
Humans
Ischemic Stroke
Stroke - genetics
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Cerebral ischemic stroke and glioma are the two leading causes of patient mortality globally. Despite physiological variations, 1 in 10 people who have an ischemic stroke go on to develop brain cancer, most notably gliomas. In addition, glioma treatments have also been shown to increase the risk of ischemic strokes. Stroke occurs more frequently in cancer patients than in the general population, according to traditional literature. Unbelievably, these events share multiple pathways, but the precise mechanism underlying their co-occurrence remains unknown. Transcription factors (TFs), the main components of gene expression programmes, finally determine the fate of cells and homeostasis. Both ischemic stroke and glioma exhibit aberrant expression of a large number of TFs, which are strongly linked to the pathophysiology and progression of both diseases. The precise genomic binding locations of TFs and how TF binding ultimately relates to transcriptional regulation remain elusive despite a strong interest in understanding how TFs regulate gene expression in both stroke and glioma. As a result, the importance of continuing efforts to understand TF-mediated gene regulation is highlighted in this review, along with some of the primary shared events in stroke and glioma.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2023.04.006