Thromboelastography as a predictor of functional outcome in acute ischemic stroke patients undergoing endovascular treatment

• Published in: Thrombosis research 2023-05, Vol.225, p.95-100
• Main Authors: Ryu, Jae-Chan, Jung, Seunguk, Bae, Jae-Han, Ha, Sang Hee, Kim, Bum Joon, Jeon, Sang-Beom, Kang, Dong-Wha, Kwon, Sun U., Kim, Jong S., Chang, Jun Young
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Brain Ischemia - etiology; Brain Ischemia - surgery; Endovascular Procedures; Endovascular treatment; Female; Humans; Hypercoagulability; Ischemic stroke; Ischemic Stroke - surgery; Male; Middle Aged; Reaction time; Stroke - etiology; Stroke - surgery; Thrombectomy; Thrombelastography; Thromboelastography; Treatment Outcome
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2023.03.015

Thromboelastography (TEG) is a useful for predicting hemorrhagic transformation, early neurological deterioration, and functional outcome after stroke. We aimed to investigate whether TEG value could also be useful in predicting functional outcome via various intraprocedural and postprocedural factors in patients with acute large vessel occlusive stroke who underwent intraarterial thrombectomy (IAT). Patients with ischemic stroke who underwent IAT between March 2018 and March 2020 at two tertiary hospitals were included. The association between reaction time (R) and functional outcome was evaluated. The primary outcome was the achievement of functional independence defined as the achievement of a modified Rankin Scale (mRS) score of 0–2 at 3 months after the index stroke. Among a total of 160 patients (mean age, 70.6 ± 12.3 years; 103 [64.4 %] men), 79 (49.3 %) achieved functional independence at 3 months. R, both as a continuous (odds ratio [OR]: 1.45, 95 % confidence interval [95 % CI]: 1.09–1.92, P = 0.011) and dichotomized parameters (R