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Sex differences in cardiovascular and disease-related features in axial spondyloarthritis. A multicenter study of 912 patients
To determine the potential impact of sex-specific disease-related characteristics on cardiovascular (CV) disease in axial spondyloarthritis (axSpA). Cross-sectional study of the Spanish AtheSpAin cohort to study CV disease in axSpA. Data on carotid ultrasound and CV disease and disease-related featu...
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| Published in: | Seminars in arthritis and rheumatism 2023-06, Vol.60, p.152198-152198, Article 152198 |
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| creator | Ferraz-Amaro, Iván Genre, Fernanda Blanco, Ricardo Corrales, Alfonso Mazón, Iñigo González Portilla, Virginia Aurrecoechea, Elena Mata, Cristina Hernández-Hernández, Vanesa Quevedo-Abeledo, Juan Carlos Rodríguez-Lozano, Carlos Lopez-Medina, Clementina Ladehesa-Pineda, María Lourdes Castañeda, Santos Vicente, Esther F. Fernández-Carballido, Cristina Martínez-Vidal, M. Paz Castro-Corredor, David Anino-Fernández, Joaquín Peiteado, Diana Plasencia-Rodríguez, Chamaida Vivar, María Luz García Galíndez-Agirregoikoa, Eva Vegas-Revenga, Nuria Urionagüena-Onaindia, Irati Perez, Esther Montes Díaz, Carlos Fernández González-Gay, Miguel Ángel Rueda-Gotor, Javier |
| description | To determine the potential impact of sex-specific disease-related characteristics on cardiovascular (CV) disease in axial spondyloarthritis (axSpA).
Cross-sectional study of the Spanish AtheSpAin cohort to study CV disease in axSpA. Data on carotid ultrasound and CV disease and disease-related features were collected.
611 men and 301 women were recruited. Classic CV risk factors were significantly less prevalent in women, who also showed a lower frequency of carotid plaques (p = 0.001), lower carotid intima-media thickness (IMT) values (p |
| doi_str_mv | 10.1016/j.semarthrit.2023.152198 |
| format | article |
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Cross-sectional study of the Spanish AtheSpAin cohort to study CV disease in axSpA. Data on carotid ultrasound and CV disease and disease-related features were collected.
611 men and 301 women were recruited. Classic CV risk factors were significantly less prevalent in women, who also showed a lower frequency of carotid plaques (p = 0.001), lower carotid intima-media thickness (IMT) values (p<0.001) and CV events (p = 0.008). However, after adjustment for classic CV risk factors, only the differences with respect to carotid IMT remained statistically significant. Women showed higher ESR at diagnosis (p = 0.038), and more active disease (ASDAS, p = 0.012, and BASDAI, p<0.001). They had shorter disease duration (p<0.001), lower prevalence of psoriasis (p = 0.008), less structural damage (mSASSS, p<0.001), and less mobility limitation (BASMI, p = 0.033). To establish whether these findings could lead to sex differences in CV disease burden, we compared the prevalence of carotid plaques in men and women with the same level of CV risk stratified according to the Systematic Coronary Risk Evaluation (SCORE). Men included in the low-moderate CV risk SCORE category had more carotid plaques (p = 0.050), along with longer disease duration (p = 0.004), higher mSASSS (p = 0.001) and psoriasis (p = 0.023). In contrast, in the high-very high-risk SCORE category, carotid plaques were observed more frequently in women (p = 0.028), who were characterized as having worse BASFI (p = 0.011), BASDAI (p<0.001) and ASDAS (p = 0.027).
Disease-related features may influence the expression of atherosclerosis in patients with axSpA. This may be especially applicable to women at high CV risk, characterized by greater disease severity and more severe subclinical atherosclerosis than men, suggesting a stronger interaction between disease activity and atherosclerosis in women with axSpA.</description><identifier>ISSN: 0049-0172</identifier><identifier>EISSN: 1532-866X</identifier><identifier>DOI: 10.1016/j.semarthrit.2023.152198</identifier><identifier>PMID: 37058848</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Atherosclerosis ; Atherosclerosis - epidemiology ; Axial Spondyloarthritis ; Cardiovascular ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Female ; Humans ; Male ; Plaque, Atherosclerotic ; Psoriasis ; Sex ; Sex Characteristics ; Women</subject><ispartof>Seminars in arthritis and rheumatism, 2023-06, Vol.60, p.152198-152198, Article 152198</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-90dd4e04a536c8a495c6089537eb02dc1fd64cca99e3b7e4870851e09e259a183</citedby><cites>FETCH-LOGICAL-c374t-90dd4e04a536c8a495c6089537eb02dc1fd64cca99e3b7e4870851e09e259a183</cites><orcidid>0000-0002-1970-541X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37058848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferraz-Amaro, Iván</creatorcontrib><creatorcontrib>Genre, Fernanda</creatorcontrib><creatorcontrib>Blanco, Ricardo</creatorcontrib><creatorcontrib>Corrales, Alfonso</creatorcontrib><creatorcontrib>Mazón, Iñigo González</creatorcontrib><creatorcontrib>Portilla, Virginia</creatorcontrib><creatorcontrib>Aurrecoechea, Elena</creatorcontrib><creatorcontrib>Mata, Cristina</creatorcontrib><creatorcontrib>Hernández-Hernández, Vanesa</creatorcontrib><creatorcontrib>Quevedo-Abeledo, Juan Carlos</creatorcontrib><creatorcontrib>Rodríguez-Lozano, Carlos</creatorcontrib><creatorcontrib>Lopez-Medina, Clementina</creatorcontrib><creatorcontrib>Ladehesa-Pineda, María Lourdes</creatorcontrib><creatorcontrib>Castañeda, Santos</creatorcontrib><creatorcontrib>Vicente, Esther F.</creatorcontrib><creatorcontrib>Fernández-Carballido, Cristina</creatorcontrib><creatorcontrib>Martínez-Vidal, M. Paz</creatorcontrib><creatorcontrib>Castro-Corredor, David</creatorcontrib><creatorcontrib>Anino-Fernández, Joaquín</creatorcontrib><creatorcontrib>Peiteado, Diana</creatorcontrib><creatorcontrib>Plasencia-Rodríguez, Chamaida</creatorcontrib><creatorcontrib>Vivar, María Luz García</creatorcontrib><creatorcontrib>Galíndez-Agirregoikoa, Eva</creatorcontrib><creatorcontrib>Vegas-Revenga, Nuria</creatorcontrib><creatorcontrib>Urionagüena-Onaindia, Irati</creatorcontrib><creatorcontrib>Perez, Esther Montes</creatorcontrib><creatorcontrib>Díaz, Carlos Fernández</creatorcontrib><creatorcontrib>González-Gay, Miguel Ángel</creatorcontrib><creatorcontrib>Rueda-Gotor, Javier</creatorcontrib><title>Sex differences in cardiovascular and disease-related features in axial spondyloarthritis. A multicenter study of 912 patients</title><title>Seminars in arthritis and rheumatism</title><addtitle>Semin Arthritis Rheum</addtitle><description>To determine the potential impact of sex-specific disease-related characteristics on cardiovascular (CV) disease in axial spondyloarthritis (axSpA).
Cross-sectional study of the Spanish AtheSpAin cohort to study CV disease in axSpA. Data on carotid ultrasound and CV disease and disease-related features were collected.
611 men and 301 women were recruited. Classic CV risk factors were significantly less prevalent in women, who also showed a lower frequency of carotid plaques (p = 0.001), lower carotid intima-media thickness (IMT) values (p<0.001) and CV events (p = 0.008). However, after adjustment for classic CV risk factors, only the differences with respect to carotid IMT remained statistically significant. Women showed higher ESR at diagnosis (p = 0.038), and more active disease (ASDAS, p = 0.012, and BASDAI, p<0.001). They had shorter disease duration (p<0.001), lower prevalence of psoriasis (p = 0.008), less structural damage (mSASSS, p<0.001), and less mobility limitation (BASMI, p = 0.033). To establish whether these findings could lead to sex differences in CV disease burden, we compared the prevalence of carotid plaques in men and women with the same level of CV risk stratified according to the Systematic Coronary Risk Evaluation (SCORE). Men included in the low-moderate CV risk SCORE category had more carotid plaques (p = 0.050), along with longer disease duration (p = 0.004), higher mSASSS (p = 0.001) and psoriasis (p = 0.023). In contrast, in the high-very high-risk SCORE category, carotid plaques were observed more frequently in women (p = 0.028), who were characterized as having worse BASFI (p = 0.011), BASDAI (p<0.001) and ASDAS (p = 0.027).
Disease-related features may influence the expression of atherosclerosis in patients with axSpA. This may be especially applicable to women at high CV risk, characterized by greater disease severity and more severe subclinical atherosclerosis than men, suggesting a stronger interaction between disease activity and atherosclerosis in women with axSpA.</description><subject>Atherosclerosis</subject><subject>Atherosclerosis - epidemiology</subject><subject>Axial Spondyloarthritis</subject><subject>Cardiovascular</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Plaque, Atherosclerotic</subject><subject>Psoriasis</subject><subject>Sex</subject><subject>Sex Characteristics</subject><subject>Women</subject><issn>0049-0172</issn><issn>1532-866X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi1ERZeWv4B85JIwduLYPpaKAlIlDlCpN8trT4RX2WTxOFX3wm8nqyxw5DTS6Hnn42GMC6gFiO79ribc-1x-5FRqCbKphZLCmhdsI1QjK9N1jy_ZBqC1FQgtL9lroh2AEB3oV-yy0aCMac2G_fqGzzymvseMY0DiaeTB55imJ09hHnzmfowLQegJq4yDLxh5j77MecX9c_IDp8M0xuMwna9KVPMbvp-HkgKOBTOnMscjn3puheQHX9LSpmt20fuB8M25XrGHu4_fbz9X918_fbm9ua9Co9tSWYixRWi9arpgfGtV6MBY1WjcgoxB9LFrQ_DWYrPV2BoNRgkEi1JZL0xzxd6tcw95-jkjFbdPFHAY_IjTTE4aEFZbrfSCmhUNeSLK2LtDTovsoxPgTvbdzv2z70723Wp_ib49b5m3e4x_g390L8CHFcDl16eE2VFIJ-8xZQzFxSn9f8tvNHidkw</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Ferraz-Amaro, Iván</creator><creator>Genre, Fernanda</creator><creator>Blanco, Ricardo</creator><creator>Corrales, Alfonso</creator><creator>Mazón, Iñigo González</creator><creator>Portilla, Virginia</creator><creator>Aurrecoechea, Elena</creator><creator>Mata, Cristina</creator><creator>Hernández-Hernández, Vanesa</creator><creator>Quevedo-Abeledo, Juan Carlos</creator><creator>Rodríguez-Lozano, Carlos</creator><creator>Lopez-Medina, Clementina</creator><creator>Ladehesa-Pineda, María Lourdes</creator><creator>Castañeda, Santos</creator><creator>Vicente, Esther F.</creator><creator>Fernández-Carballido, Cristina</creator><creator>Martínez-Vidal, M. Paz</creator><creator>Castro-Corredor, David</creator><creator>Anino-Fernández, Joaquín</creator><creator>Peiteado, Diana</creator><creator>Plasencia-Rodríguez, Chamaida</creator><creator>Vivar, María Luz García</creator><creator>Galíndez-Agirregoikoa, Eva</creator><creator>Vegas-Revenga, Nuria</creator><creator>Urionagüena-Onaindia, Irati</creator><creator>Perez, Esther Montes</creator><creator>Díaz, Carlos Fernández</creator><creator>González-Gay, Miguel Ángel</creator><creator>Rueda-Gotor, Javier</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1970-541X</orcidid></search><sort><creationdate>202306</creationdate><title>Sex differences in cardiovascular and disease-related features in axial spondyloarthritis. A multicenter study of 912 patients</title><author>Ferraz-Amaro, Iván ; Genre, Fernanda ; Blanco, Ricardo ; Corrales, Alfonso ; Mazón, Iñigo González ; Portilla, Virginia ; Aurrecoechea, Elena ; Mata, Cristina ; Hernández-Hernández, Vanesa ; Quevedo-Abeledo, Juan Carlos ; Rodríguez-Lozano, Carlos ; Lopez-Medina, Clementina ; Ladehesa-Pineda, María Lourdes ; Castañeda, Santos ; Vicente, Esther F. ; Fernández-Carballido, Cristina ; Martínez-Vidal, M. Paz ; Castro-Corredor, David ; Anino-Fernández, Joaquín ; Peiteado, Diana ; Plasencia-Rodríguez, Chamaida ; Vivar, María Luz García ; Galíndez-Agirregoikoa, Eva ; Vegas-Revenga, Nuria ; Urionagüena-Onaindia, Irati ; Perez, Esther Montes ; Díaz, Carlos Fernández ; González-Gay, Miguel Ángel ; Rueda-Gotor, Javier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-90dd4e04a536c8a495c6089537eb02dc1fd64cca99e3b7e4870851e09e259a183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Atherosclerosis</topic><topic>Atherosclerosis - epidemiology</topic><topic>Axial Spondyloarthritis</topic><topic>Cardiovascular</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Carotid Intima-Media Thickness</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Plaque, Atherosclerotic</topic><topic>Psoriasis</topic><topic>Sex</topic><topic>Sex Characteristics</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferraz-Amaro, Iván</creatorcontrib><creatorcontrib>Genre, Fernanda</creatorcontrib><creatorcontrib>Blanco, Ricardo</creatorcontrib><creatorcontrib>Corrales, Alfonso</creatorcontrib><creatorcontrib>Mazón, Iñigo González</creatorcontrib><creatorcontrib>Portilla, Virginia</creatorcontrib><creatorcontrib>Aurrecoechea, Elena</creatorcontrib><creatorcontrib>Mata, Cristina</creatorcontrib><creatorcontrib>Hernández-Hernández, Vanesa</creatorcontrib><creatorcontrib>Quevedo-Abeledo, Juan Carlos</creatorcontrib><creatorcontrib>Rodríguez-Lozano, Carlos</creatorcontrib><creatorcontrib>Lopez-Medina, Clementina</creatorcontrib><creatorcontrib>Ladehesa-Pineda, María Lourdes</creatorcontrib><creatorcontrib>Castañeda, Santos</creatorcontrib><creatorcontrib>Vicente, Esther F.</creatorcontrib><creatorcontrib>Fernández-Carballido, Cristina</creatorcontrib><creatorcontrib>Martínez-Vidal, M. Paz</creatorcontrib><creatorcontrib>Castro-Corredor, David</creatorcontrib><creatorcontrib>Anino-Fernández, Joaquín</creatorcontrib><creatorcontrib>Peiteado, Diana</creatorcontrib><creatorcontrib>Plasencia-Rodríguez, Chamaida</creatorcontrib><creatorcontrib>Vivar, María Luz García</creatorcontrib><creatorcontrib>Galíndez-Agirregoikoa, Eva</creatorcontrib><creatorcontrib>Vegas-Revenga, Nuria</creatorcontrib><creatorcontrib>Urionagüena-Onaindia, Irati</creatorcontrib><creatorcontrib>Perez, Esther Montes</creatorcontrib><creatorcontrib>Díaz, Carlos Fernández</creatorcontrib><creatorcontrib>González-Gay, Miguel Ángel</creatorcontrib><creatorcontrib>Rueda-Gotor, Javier</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferraz-Amaro, Iván</au><au>Genre, Fernanda</au><au>Blanco, Ricardo</au><au>Corrales, Alfonso</au><au>Mazón, Iñigo González</au><au>Portilla, Virginia</au><au>Aurrecoechea, Elena</au><au>Mata, Cristina</au><au>Hernández-Hernández, Vanesa</au><au>Quevedo-Abeledo, Juan Carlos</au><au>Rodríguez-Lozano, Carlos</au><au>Lopez-Medina, Clementina</au><au>Ladehesa-Pineda, María Lourdes</au><au>Castañeda, Santos</au><au>Vicente, Esther F.</au><au>Fernández-Carballido, Cristina</au><au>Martínez-Vidal, M. Paz</au><au>Castro-Corredor, David</au><au>Anino-Fernández, Joaquín</au><au>Peiteado, Diana</au><au>Plasencia-Rodríguez, Chamaida</au><au>Vivar, María Luz García</au><au>Galíndez-Agirregoikoa, Eva</au><au>Vegas-Revenga, Nuria</au><au>Urionagüena-Onaindia, Irati</au><au>Perez, Esther Montes</au><au>Díaz, Carlos Fernández</au><au>González-Gay, Miguel Ángel</au><au>Rueda-Gotor, Javier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in cardiovascular and disease-related features in axial spondyloarthritis. A multicenter study of 912 patients</atitle><jtitle>Seminars in arthritis and rheumatism</jtitle><addtitle>Semin Arthritis Rheum</addtitle><date>2023-06</date><risdate>2023</risdate><volume>60</volume><spage>152198</spage><epage>152198</epage><pages>152198-152198</pages><artnum>152198</artnum><issn>0049-0172</issn><eissn>1532-866X</eissn><abstract>To determine the potential impact of sex-specific disease-related characteristics on cardiovascular (CV) disease in axial spondyloarthritis (axSpA).
Cross-sectional study of the Spanish AtheSpAin cohort to study CV disease in axSpA. Data on carotid ultrasound and CV disease and disease-related features were collected.
611 men and 301 women were recruited. Classic CV risk factors were significantly less prevalent in women, who also showed a lower frequency of carotid plaques (p = 0.001), lower carotid intima-media thickness (IMT) values (p<0.001) and CV events (p = 0.008). However, after adjustment for classic CV risk factors, only the differences with respect to carotid IMT remained statistically significant. Women showed higher ESR at diagnosis (p = 0.038), and more active disease (ASDAS, p = 0.012, and BASDAI, p<0.001). They had shorter disease duration (p<0.001), lower prevalence of psoriasis (p = 0.008), less structural damage (mSASSS, p<0.001), and less mobility limitation (BASMI, p = 0.033). To establish whether these findings could lead to sex differences in CV disease burden, we compared the prevalence of carotid plaques in men and women with the same level of CV risk stratified according to the Systematic Coronary Risk Evaluation (SCORE). Men included in the low-moderate CV risk SCORE category had more carotid plaques (p = 0.050), along with longer disease duration (p = 0.004), higher mSASSS (p = 0.001) and psoriasis (p = 0.023). In contrast, in the high-very high-risk SCORE category, carotid plaques were observed more frequently in women (p = 0.028), who were characterized as having worse BASFI (p = 0.011), BASDAI (p<0.001) and ASDAS (p = 0.027).
Disease-related features may influence the expression of atherosclerosis in patients with axSpA. This may be especially applicable to women at high CV risk, characterized by greater disease severity and more severe subclinical atherosclerosis than men, suggesting a stronger interaction between disease activity and atherosclerosis in women with axSpA.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37058848</pmid><doi>10.1016/j.semarthrit.2023.152198</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1970-541X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-0172 |
| ispartof | Seminars in arthritis and rheumatism, 2023-06, Vol.60, p.152198-152198, Article 152198 |
| issn | 0049-0172 1532-866X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2801979757 |
| source | ScienceDirect Freedom Collection |
| subjects | Atherosclerosis Atherosclerosis - epidemiology Axial Spondyloarthritis Cardiovascular Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Carotid Intima-Media Thickness Cross-Sectional Studies Female Humans Male Plaque, Atherosclerotic Psoriasis Sex Sex Characteristics Women |
| title | Sex differences in cardiovascular and disease-related features in axial spondyloarthritis. A multicenter study of 912 patients |
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