Mechanisms of circRNA/lncRNA-miRNA interactions and applications in disease and drug research

In recent years, breakthroughs in bioinformatics have been made with the discovery of many functionally significant non-coding RNAs (ncRNAs). The discovery of these ncRNAs has further demonstrated the multi-level characteristics of intracellular gene expression regulation, which plays an important r...

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Published in:Biomedicine & pharmacotherapy 2023-06, Vol.162, p.114672-114672, Article 114672
Main Authors: Ma, Benchi, Wang, Shihao, Wu, Wenzheng, Shan, Pufan, Chen, Yufan, Meng, Jiaqi, Xing, Liping, Yun, Jingyi, Hao, Longhui, Wang, Xiaoyu, Li, Shuyan, Guo, Yinghui
Format: Article
Language:English
Subjects:
CeRNA
CircRNA
Computational Biology
Disease
Gene Expression Regulation
LncRNA
MicroRNAs - genetics
MiRNA
MiRNA sponges
RNA, Circular - genetics
RNA, Long Noncoding - genetics
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Summary:In recent years, breakthroughs in bioinformatics have been made with the discovery of many functionally significant non-coding RNAs (ncRNAs). The discovery of these ncRNAs has further demonstrated the multi-level characteristics of intracellular gene expression regulation, which plays an important role in assisting diagnosis, guiding clinical drug use and determining prognosis in the treatment process of various diseases. microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) are the three major types of ncRNAs that interact with each other. Studies have shown that lncRNAs and circRNAs can sponge miRNAs, thereby influencing normal physiological processes and regulating mRNA expression and, thus, the physiological state of cells. This paper summarizes the mechanism of action and research progress of the three ncRNA and seven types of modalities. This summary is intended to provide new ideas for diagnosing and treating diseases and researching and developing new drugs. [Display omitted]
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2023.114672