Long-Term Outcomes in IgA Nephropathy

IgA nephropathy can progress to kidney failure, and risk assessment soon after diagnosis has advantages both for clinical management and the development of new therapeutics. We present relationships among proteinuria, eGFR slope, and lifetime risks for kidney failure. The IgA nephropathy cohort (229...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2023-06, Vol.18 (6), p.727-738
Main Authors: Pitcher, David, Braddon, Fiona, Hendry, Bruce, Mercer, Alex, Osmaston, Kate, Saleem, Moin A, Steenkamp, Retha, Wong, Katie, Turner, A Neil, Wang, Kaijun, Gale, Daniel P, Barratt, Jonathan
Format: Article
Language:English
Subjects:
Adult
Child
Disease Progression
Glomerular Filtration Rate
Glomerulonephritis, IGA - complications
Glomerulonephritis, IGA - epidemiology
Humans
Kidney
Kidney Failure, Chronic - therapy
Proteinuria - etiology
Retrospective Studies
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Summary:IgA nephropathy can progress to kidney failure, and risk assessment soon after diagnosis has advantages both for clinical management and the development of new therapeutics. We present relationships among proteinuria, eGFR slope, and lifetime risks for kidney failure. The IgA nephropathy cohort (2299 adults and 140 children) of the UK National Registry of Rare Kidney Diseases (RaDaR) was analyzed. Patients enrolled had a biopsy-proven diagnosis of IgA nephropathy plus proteinuria >0.5 g/d or eGFR
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.0000000000000135