C6orf15 acts as a potential novel marker of adverse pathological features and prognosis for colon cancer

To investigate the expression of chromosome 6 open reading frame 15 (C6orf15) in colon cancer and its effects on clinicopathological features and prognosis. Using the transcriptome and clinical data of colon cancer and normal tissues in The Cancer Genome Atlas (TCGA) database, the expression of C6or...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 2023-05, Vol.245, p.154426-154426, Article 154426
Main Authors: Xiong, Xiaoyu, Wang, Shuo, Gao, Zhidong, Ye, Yingjiang
Format: Article
Language:English
Subjects:
Chromosome 6 open reading frame 15
Colon cancer
Colonic Neoplasms - pathology
Hedgehog Proteins
Humans
Lymphatic Metastasis
Prognosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the expression of chromosome 6 open reading frame 15 (C6orf15) in colon cancer and its effects on clinicopathological features and prognosis. Using the transcriptome and clinical data of colon cancer and normal tissues in The Cancer Genome Atlas (TCGA) database, the expression of C6orf15 mRNA in colon cancer samples and its relationship with clinicopathological characteristics and prognosis were explored. The expression level of C6orf15 protein in 23 colon cancer tissues was detected by immunohistochemistry (IHC). The possible mechanism of C6orf15 involved in the occurrence and development of colon cancer was explored by gene set enrichment analysis (GSEA). Compared with normal tissues, C6orf15 was highly expressed in colon cancer (1.207 ± 0.694 vs 0.276 ± 0.166, t = 8.281, P 
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2023.154426