Role of Systemic Inflammatory Markers in Pediatric Kidney Transplantation

• Published in: Transplantation proceedings 2023-06, Vol.55 (5), p.1152-1155
• Main Authors: Taner, Sevgin, Goktepe, Berk, Zaman, Ece Irem, Asci, Gulay, Bulut, Ipek Kaplan, Toz, Huseyin, Sarsik, Banu, Firat, Ozgur, Kizilkaya, Ali Ekber, Kabasakal, Caner, Keskinoğlu, Ahmet
• Format: Article
• Language: English
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2023.03.030

•Chronic allograft dysfunction is a histopathologic definition that describes slow-type rejection, chronic interstitial fibrosis, and tubular atrophy of the allograft due to chronic inflammatory processes, leading to graft loss over the years.•The possibility of a chance to determine the risk of kidney transplant patients noninvasively indicates that ongoing research is needed to identify biomarkers.•Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, systemic immune-inflammation index, and neutrophil percentage-albumin ratio (NPAR) values are correlated with creatinine levels after 5 years of kidney transplantation.•The median NPAR of the patients with chronic allograft dysfunction at the last visit was found to be higher than the group without chronic allograft dysfunction.•NPAR, may be a candidate to be an indicator of ongoing inflammation in the graft. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII = N × P/L), and neutrophil percentage-albumin ratio (NPAR) have become accepted markers of inflammation in recent years. These indices are used as indicators of disease activity, mortality, and morbidity in many diseases. This study evaluated the relationship between inflammatory indices and graft function in pediatric kidney transplant recipients. Medical records of pediatric patients who underwent kidney transplantation at Ege University between 1995 and 2020 were reviewed retrospectively. Demographic, clinical, and laboratory data were recorded during the third month, first year, and fifth year of transplantation and at the last visit. The median age of the 119 patients (60 boys/59 girls) at the time of transplantation was 154 months, and the median follow-up period was 101 months. According to Spearman correlation analysis, patients' final creatinine levels were positively correlated with NLR (r = 0.319), PLR (r = 0.219), SII (r = 0.214), and NPAR (r = 0.347) of the last visit; final estimate glomerular filtration rate levels were negatively correlated with NLR (P = .010, r = −0.250) and NPAR (P = .004, r = −0.277). The median NPAR of the patients with chronic allograft dysfunction at the last visit was found to be statistically significantly higher than without (P = .032). NLR, PLR, SII, and NPAR values are correlated with creatinine levels after 5 years of kidney transplantation. The NPAR and final creatinine levels had the highest correlation coefficient among these inflammatory markers.