The association between platelet reactivity and lipoprotein levels in Framingham Heart Study participants

Hypertriglyceridemia is an independent risk factor for major adverse cardiovascular events, though the mechanisms linking triglycerides and platelet function with thrombosis, remain elusive. The aim of this study was to assess the association between platelet function and triglyceride levels. We inc...

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Bibliographic Details
Published in:Thrombosis research 2023-05, Vol.225, p.103-109
Main Authors: Nkambule, Bongani Brian, Chan, Melissa Victoria, Lachapelle, Amber Rose, Grech, Joseph, Thibord, Florian, Chen, Ming-Huei, Johnson, Andrew Danner
Format: Article
Language:English
Subjects:
Cholesterol
Granules
Humans
Hypertriglyceridemia - drug therapy
Lipoproteins, LDL
Longitudinal Studies
Platelets
thrombus
Triglycerides
Triglycerides - therapeutic use
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Summary:Hypertriglyceridemia is an independent risk factor for major adverse cardiovascular events, though the mechanisms linking triglycerides and platelet function with thrombosis, remain elusive. The aim of this study was to assess the association between platelet function and triglyceride levels. We included participants from the Framingham Heart Study Third Generation cohort, OMNI, and New Offspring Spouse cohort who attended the third examination cycle (2016–2019). Eligible participants were categorized into four triglyceride subgroups. The study comprised a total of 1897 (55.53 %) participants with normal TG levels; 883 (25.85 %) participants with high-normal TGs; 378 (11.07 %) with borderline high TGs; and 258 (7.55 %) participants with hypertriglyceridemia. After adjusting for age, sex, alcohol consumption, aspirin, statin and P2Y12 inhibitors, the levels of ADP-induced platelet aggregation were inversely associated with total cholesterol levels (P 
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2023.03.013