The 2021 WHO Classification for Gliomas and Implications on Imaging Diagnosis: Part 2—Summary of Imaging Findings on Pediatric‐Type Diffuse High‐Grade Gliomas, Pediatric‐Type Diffuse Low‐Grade Gliomas, and Circumscribed Astrocytic Gliomas

The fifth edition of the World Health Organization (WHO) classification of central nervous system tumors published in 2021 advances the role of molecular diagnostics in the classification of gliomas by emphasizing integrated diagnoses based on histopathology and molecular information and grouping tu...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2023-09, Vol.58 (3), p.690-708
Main Authors: Park, Yae Won, Vollmuth, Philipp, Foltyn‐Dumitru, Martha, Sahm, Felix, Ahn, Sung Soo, Chang, Jong Hee, Kim, Se Hoon
Format: Article
Language:English
Subjects:
Astrocytoma - diagnostic imaging
Brain cancer
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - genetics
Brain tumors
Central nervous system
Central Nervous System Neoplasms
Child
Classification
Glioma
Glioma - diagnostic imaging
Glioma - genetics
Histopathology
Humans
Imaging
Magnetic resonance imaging
Mutation
Pediatrics
Tumors
World Health Organization
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Summary:The fifth edition of the World Health Organization (WHO) classification of central nervous system tumors published in 2021 advances the role of molecular diagnostics in the classification of gliomas by emphasizing integrated diagnoses based on histopathology and molecular information and grouping tumors based on genetic alterations. This Part 2 review focuses on the molecular diagnostics and imaging findings of pediatric‐type diffuse high‐grade gliomas, pediatric‐type diffuse low‐grade gliomas, and circumscribed astrocytic gliomas. Each tumor type in pediatric‐type diffuse high‐grade glioma mostly harbors a distinct molecular marker. On the other hand, in pediatric‐type diffuse low‐grade gliomas and circumscribed astrocytic gliomas, molecular diagnostics may be extremely complicated at a glance in the 2021 WHO classification. It is crucial for radiologists to understand the molecular diagnostics and imaging findings and leverage the knowledge in clinical practice. Evidence Level 3 Technical Efficacy Stage 3.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.28740