Phospholipid‐Coated Boronic Oxide Nanoparticles as Boron Agents for Boron Neutron Capture Therapy

Minimally invasive boron neutron capture therapy (BNCT) is an elegant approach for cancer treatment. The highly selective and efficient deliverability of boron agents to cancer cells is the key to maximizing the therapeutic benefits of BNCT. In addition, enhancement of the frequencies to achieve bor...

Full description

Saved in:
Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2023-08, Vol.24 (15), p.e202300186-n/a
Main Authors: Kawasaki, Riku, Hirano, Hidetoshi, Yamana, Keita, Oshige, Ayano, Nishimura, Kotaro, Kono, Nanami, Sanada, Yu, Bando, Kaori, Tabata, Anri, Yasukawa, Naoki, Azuma, Hideki, Takata, Takushi, Sakurai, Yoshinori, Tanaka, Hiroki, Suzuki, Minoru, Tarutani, Naoki, Katagiri, Kiyofumi, Nagasaki, Takeshi, Ikeda, Atsushi
Format: Article
Language:English
Subjects:
Boron
Boron Compounds - therapeutic use
Boron Neutron Capture Therapy
Cancer
Cancer therapies
drug delivery systems
Irradiation
lipid nanoparticles
Nanoparticles
Neutron beams
Neutron irradiation
Nuclear capture
organic–inorganic hybrid nanomaterials
Oxides
Phospholipids
Spheroids
Thermal neutrons
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Minimally invasive boron neutron capture therapy (BNCT) is an elegant approach for cancer treatment. The highly selective and efficient deliverability of boron agents to cancer cells is the key to maximizing the therapeutic benefits of BNCT. In addition, enhancement of the frequencies to achieve boron neutron capture reaction is also significant in improving therapeutic efficacy by providing a highly concentrated boron agent in each boron nanoparticle. As the density of the thermal neutron beam remains low, it is unable to induce high‐efficiency cell destruction. Herein, we report phospholipid‐coated boronic oxide nanoparticles as agents for BNCT that can provide a highly concentrated boron atom in each nanoparticle. The current system exhibited in vitro BNCT activity seven times higher than that of commercial boron agents. Furthermore, the system could penetrate cancer spheroids deeply, efficiently suppressing thermal neutron irradiation‐induced growth. Gotcha! Phospholipid‐coated boronic oxide nanoparticles exhibited excellent BNCT activity in cancer spheroids through efficient penetration and the provision of highly concentrated boron atoms in nanoparticles.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202300186