Immunological profile of two canine breeds in an endemic region of Leishmania infantum

Visceral leishmaniosis is the one of the most important protozoal zoonoses in Europe, and it is caused by Leishmania infantum, an intracellular protozoan parasite. The disease is endemic in dogs in the Mediterranean area. The main goal of this work is to correlate the levels of several cytokines lin...

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Bibliographic Details
Published in:Veterinary parasitology (Amsterdam) 2023-05, Vol.40, p.100861-100861, Article 100861
Main Authors: Macià, María, Marín-García, Pablo-Jesús, Ahuir-Baraja, Ana-Elena, Llobat, Lola
Format: Article
Language:English
Subjects:
Animals
Breed
Canine leishmaniosis
Cytokines
Dogs
Immunological profile
Interleukin-18
Interleukin-2
Interleukin-6
Interleukin-8
Leishmania infantum
Tumor Necrosis Factor-alpha
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Summary:Visceral leishmaniosis is the one of the most important protozoal zoonoses in Europe, and it is caused by Leishmania infantum, an intracellular protozoan parasite. The disease is endemic in dogs in the Mediterranean area. The main goal of this work is to correlate the levels of several cytokines linked to immune response against L. infantum infection in two canine breeds. Thirty-one Boxer and twenty-eight Ibizan Hound dogs living in the Valencian Community (East coast of Spain) were analyzed for the presence of anti-Leishmania antibodies in serum by IFAT test. Cytokines IFN-γ, TNF-α, IL-2, IL-6, IL-8, and IL-18 were determined by ELISA commercial tests. The levels of IFN-γ, IL-2, and IL-18 in our study, cytokines linked to a cellular immune response, were higher (p 
ISSN:2405-9390
2405-9390
DOI:10.1016/j.vprsr.2023.100861