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d‐Amino acids in biological systems
Investigations on the occurrence and biochemical roles of free D‐amino acids and D‐amino acid‐containing peptides and proteins in living systems have increased in frequency and significance. Their occurrence and roles may vary substantially with progression from microbiotic to evermore advanced macr...
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| Published in: | Chirality (New York, N.Y.) N.Y.), 2023-09, Vol.35 (9), p.508-534 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c3932-6c5772158312eceadbd013161dce999992d0f55d28cfd1915b3d4918a44093063 |
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| cites | cdi_FETCH-LOGICAL-c3932-6c5772158312eceadbd013161dce999992d0f55d28cfd1915b3d4918a44093063 |
| container_end_page | 534 |
| container_issue | 9 |
| container_start_page | 508 |
| container_title | Chirality (New York, N.Y.) |
| container_volume | 35 |
| creator | Du, Siqi Wey, Michael Armstrong, Daniel W. |
| description | Investigations on the occurrence and biochemical roles of free D‐amino acids and D‐amino acid‐containing peptides and proteins in living systems have increased in frequency and significance. Their occurrence and roles may vary substantially with progression from microbiotic to evermore advanced macrobiotic systems. We now understand many of the biosynthetic and regulatory pathways, which are outlined herein. Important uses for D‐amino acids in plants, invertebrates, and vertebrates are reviewed. Given its importance, a separate section on the occurrence and role of D‐amino acids in human disease is presented.
Once thought to be biologically superfluous, D‐amino acids have now been found to play important roles in disease, signaling, bioregulation, and many other areas. |
| doi_str_mv | 10.1002/chir.23562 |
| format | article |
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Once thought to be biologically superfluous, D‐amino acids have now been found to play important roles in disease, signaling, bioregulation, and many other areas.</description><subject>Amino acid oxidase</subject><subject>Amino Acids</subject><subject>Animals</subject><subject>biomarkers</subject><subject>disease</subject><subject>epimerase</subject><subject>Humans</subject><subject>Peptides</subject><subject>Proteins</subject><subject>racemase</subject><subject>Stereoisomerism</subject><subject>Vertebrates</subject><issn>0899-0042</issn><issn>1520-636X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp90M1Kw0AUhuFBFFurGy9AAiKIkHrO_CSZZSlqhYIgCu6GZGaiU_JTMw3SnZfgNXolpqa6cOFsZvPwcvgIOUYYIwC91C-uGVMmIrpDhigohBGLnnbJEBIpQwBOB-TA-wUAyIjxfTJgMcScIh-SM_P5_jEpXVUHqXbGB64KMlcX9bPTaRH4tV_Z0h-SvTwtvD3a_iPyeH31MJ2F87ub2-lkHmomGQ0jLeKYokgYUqttajIDyDBCo63cPGogF8LQROcGJYqMGS4xSTkHySBiI3Led5dN_dpav1Kl89oWRVrZuvWKJsAYwwRER0__0EXdNlV3Xad4jLSzcacueqWb2vvG5mrZuDJt1gpBbcZTm_HU93gdPtkm26y05pf-rNUB7MGbK-z6n5Sazm7v--gXpZl3CA</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Du, Siqi</creator><creator>Wey, Michael</creator><creator>Armstrong, Daniel W.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0501-6231</orcidid></search><sort><creationdate>202309</creationdate><title>d‐Amino acids in biological systems</title><author>Du, Siqi ; Wey, Michael ; Armstrong, Daniel W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3932-6c5772158312eceadbd013161dce999992d0f55d28cfd1915b3d4918a44093063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amino acid oxidase</topic><topic>Amino Acids</topic><topic>Animals</topic><topic>biomarkers</topic><topic>disease</topic><topic>epimerase</topic><topic>Humans</topic><topic>Peptides</topic><topic>Proteins</topic><topic>racemase</topic><topic>Stereoisomerism</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Siqi</creatorcontrib><creatorcontrib>Wey, Michael</creatorcontrib><creatorcontrib>Armstrong, Daniel W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chirality (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Siqi</au><au>Wey, Michael</au><au>Armstrong, Daniel W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>d‐Amino acids in biological systems</atitle><jtitle>Chirality (New York, N.Y.)</jtitle><addtitle>Chirality</addtitle><date>2023-09</date><risdate>2023</risdate><volume>35</volume><issue>9</issue><spage>508</spage><epage>534</epage><pages>508-534</pages><issn>0899-0042</issn><eissn>1520-636X</eissn><abstract>Investigations on the occurrence and biochemical roles of free D‐amino acids and D‐amino acid‐containing peptides and proteins in living systems have increased in frequency and significance. Their occurrence and roles may vary substantially with progression from microbiotic to evermore advanced macrobiotic systems. We now understand many of the biosynthetic and regulatory pathways, which are outlined herein. Important uses for D‐amino acids in plants, invertebrates, and vertebrates are reviewed. Given its importance, a separate section on the occurrence and role of D‐amino acids in human disease is presented.
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| fulltext | fulltext |
| identifier | ISSN: 0899-0042 |
| ispartof | Chirality (New York, N.Y.), 2023-09, Vol.35 (9), p.508-534 |
| issn | 0899-0042 1520-636X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2803331805 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Amino acid oxidase Amino Acids Animals biomarkers disease epimerase Humans Peptides Proteins racemase Stereoisomerism Vertebrates |
| title | d‐Amino acids in biological systems |
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