An Isomer of Galidesivir That Potently Inhibits Influenza Viruses and Members of the Bunyavirales Order

We report for the first time the antiviral activities of two iminovirs (antiviral imino-C-nucleosides) 1 and 2, structurally related to galidesivir (Immucillin A, BCX4430). An iminovir containing the 4-aminopyrrolo­[2,1-f]­[1,2,4-triazine] nucleobase found in remdesivir exhibited submicromolar inhib...

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Published in:ACS medicinal chemistry letters 2023-04, Vol.14 (4), p.506-513
Main Authors: Sparrow, Kevin J., Shrestha, Rinu, Wood, James M., Clinch, Keith, Hurst, Brett L., Wang, Hong, Gowen, Brian B., Julander, Justin G., Tarbet, E. Bart, McSweeney, Alice M., Ward, Vernon K., Evans, Gary B., Harris, Lawrence. D.
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Language:English
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Summary:We report for the first time the antiviral activities of two iminovirs (antiviral imino-C-nucleosides) 1 and 2, structurally related to galidesivir (Immucillin A, BCX4430). An iminovir containing the 4-aminopyrrolo­[2,1-f]­[1,2,4-triazine] nucleobase found in remdesivir exhibited submicromolar inhibition of multiple strains of influenza A and B viruses, as well as members of the Bunyavirales order. We also report the first syntheses of ProTide prodrugs of iminovir monophosphates, which unexpectedly displayed poorer viral inhibition than their parent nucleosides in vitro. An efficient synthesis of the 4-aminopyrrolo­[2,1-f]­[1,2,4-triazine]-containing iminovir 2 was developed to enable preliminary in vivo studies, wherein it displayed significant toxicity in BALB/c mice and limited protection against influenza. Further modification of this anti-influenza iminovir will therefore be required to improve its therapeutic value.
ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.3c00048