Role of BDNF in Neuroplasticity Associated with Alcohol Dependence

Chronic alcohol consumption is characterized by disturbances of neuroplasticity. Brain-derived neurotrophic factor (BDNF) is believed to be critically involved in this process. Here we aimed to review actual experimental and clinical data related to BDNF participation in neuroplasticity in the conte...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow) 2023-03, Vol.88 (3), p.404-416
Main Authors: Peregud, Danil I., Baronets, Valeria Yu, Terebilina, Natalia N., Gulyaeva, Natalia V.
Format: Article
Language:English
Subjects:
Alcohol
Alcohol abuse
Alcohol Drinking - psychology
Alcohol use
Alcoholism
Alcoholism - complications
Alcoholism - genetics
Alcoholism - psychology
Alcohols
Analysis
Behavioral plasticity
Biochemistry
Biomarkers
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Brain
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Cognitive ability
Dependence
Drug abuse
Drug dependence
Ethanol
Humans
Intoxication
Life Sciences
Microbiology
Neuronal Plasticity
Neuroplasticity
Polymorphism
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic alcohol consumption is characterized by disturbances of neuroplasticity. Brain-derived neurotrophic factor (BDNF) is believed to be critically involved in this process. Here we aimed to review actual experimental and clinical data related to BDNF participation in neuroplasticity in the context of alcohol dependence. As has been shown in experiments with rodents, alcohol consumption is accompanied by the brain region-specific changes of BDNF expression and by structural and behavioral impairments. BDNF reverses aberrant neuroplasticity observed during alcohol intoxication. According to the clinical data parameters associated with BDNF demonstrate close correlation with neuroplastic changes accompanying alcohol dependence. In particular, the rs6265 polymorphism within the BDNF gene is associated with macrostructural changes in the brain, while peripheral BDNF concentration may be associated with anxiety, depression, and cognitive impairment. Thus, BDNF is involved in the mechanisms of alcohol-induced changes of neuroplasticity, and polymorphisms within the BDNF gene and peripheral BDNF concentration may serve as biomarkers, diagnostic or prognostic factors in treatment of alcohol abuse.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297923030094