Topology-based radiomic features for prediction of parotid gland cancer malignancy grade in magnetic resonance images

• Published in: Magma (New York, N.Y.) N.Y.), 2023-10, Vol.36 (5), p.767-777
• Main Authors: Ikushima, Kojiro, Arimura, Hidetaka, Yasumatsu, Ryuji, Kamezawa, Hidemi, Ninomiya, Kenta
• Format: Article
• Language: English
• Subjects: Basic Science - Image analysis; Biomedical Engineering and Bioengineering; Computer Appl. in Life Sciences; Health Informatics; Imaging; Medicine; Medicine & Public Health; Radiology; Research Article; Solid State Physics
• ISSN: 1352-8661; 1352-8661
• DOI: 10.1007/s10334-023-01084-0

Purpose The malignancy grades of parotid gland cancer (PGC) have been assessed for a decision of treatment policies. Therefore, we have investigated the feasibility of topology-based radiomic features for the prediction of parotid gland cancer (PGC) malignancy grade in magnetic resonance (MR) images. Materials and methods Two-dimensional T1- and T2-weighted MR images of 39 patients with PGC were selected for this study. Imaging properties of PGC can be quantified using the topology, which could be useful for assessing the number of the k-dimensional holes or heterogeneity in PGC regions using invariants of the Betti numbers. Radiomic signatures were constructed from 41,472 features obtained after a harmonization using an elastic net model. PGC patients were stratified using a logistic classification into low/intermediate- and high-grade malignancy groups. The training data were increased by four times to avoid the overfitting problem using a synthetic minority oversampling technique. The proposed approach was assessed using a 4-fold cross-validation test. Results The highest accuracy of the proposed approach was 0.975 for the validation cases, whereas that of the conventional approach was 0.694. Conclusion This study indicated that topology-based radiomic features could be feasible for the noninvasive prediction of the malignancy grade of PGCs.