Synthesis and characterization of citrate soft rice starch: A new strategy of producing disintegrating agent for design drug and resistant starch

Assam soft rice starch (ASRS) and Citric acid-esterified Assam soft rice starch (c-ASRS) were studied extensively. FTIR, CHN, DSC, XRD, SEM, TEM and optical microscope studies were performed for native and modified starches. Powder rearrangements, cohesiveness and flowability were studied by the Kaw...

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Published in:International journal of biological macromolecules 2023-06, Vol.240, p.124475-124475, Article 124475
Main Authors: Kalita, Pratap, Ahmed, Abdul Baquee, Sen, Saikat, Pachuau, Lalduhsanga, Phukan, Mayuri
Format: Article
Language:English
Subjects:
Amylose
Assam soft rice starch
Chemistry, Pharmaceutical
Citrate-starch
Citric Acid
Excipients - chemistry
Functional materials
In vitro digestibility
Oryza
Physicochemical attributes
Resistant Starch
Solubility
Starch - chemistry
Tablets - chemistry
Tabletting properties
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Summary:Assam soft rice starch (ASRS) and Citric acid-esterified Assam soft rice starch (c-ASRS) were studied extensively. FTIR, CHN, DSC, XRD, SEM, TEM and optical microscope studies were performed for native and modified starches. Powder rearrangements, cohesiveness and flowability were studied by the Kawakita plot. Moisture and ash content was around 9 % and 0.5 %. In vitro digestibility of ASRS and c-ASRS produced functional RS. Paracetamol tablets were prepared using ASRS and c-ASRS as granulating-disintegrating agents through wet granulation methods. The prepared tablets' physical properties, disintegrant properties, in vitro dissolution and dissolution efficiency (DE) were performed. The average particle size was obtained at 6.59 ± 0.355 μm and 8.15 ± 0.168 μm for ASRS and c-ASRS, respectively. All the results were statistically significant at p 
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.124475